| Cat. No. |
Product Name |
Information |
| PC-38771 |
C598-0556
USP10 inhibitor
|
C598-0556 is a selective, small molecule inhibitor of USP10, inhibits USP10 comparably to HBX19818 (IC50=10 uM), with no inhibition against USP7 (IC50>100 uM). |
| PC-38692 |
FT709
USP9X inhibitor
|
FT709 is a potent, highly selective USP9X inhibitor with IC50 of 82 nM in biochemical assays, reduces CEP55 expression in BxPC3 pancreatic cancer cells with IC50 of 131 nM. |
| PC-73355 |
Subquinocin
CYLD inhibitor
|
Subquinocin is a small molecule inhibitor of DUB activity of CYLD with IC50 of 30 uM, enhances NF-κB activation by inhibiting CYLD. |
| PC-73353 |
USP inhibitor 1
USP33 inhibitor
|
USP inhibitor 1 is an irreversible USP inhibitor with submicromolar IC50 of USP4 and its phylogenetic relative USP11, also functionally inhibits USP33, leading to CP110 instability and synergy with ATR inhibition. |
| PC-73318 |
KSQ4279
USP1 inhibitor
|
KSQ4279 (KSQ-4279) is a potent, selective, first-in-class inhibitor of USP1, shows anti-proliferative effects in a subset of cell lines, including mutations in BRCA1/2. |
| PC-73132 |
6RK73
UCHL1 inhibitor
|
6RK73 is a potent, specific and covalent UCHL1 inhibitor with IC50 of 0.23 uM. |
| PC-72836 |
NJH-2-075
OTUB1 recruiter DUBTAC
|
NJH-2-075 is an alkyne-functionalized probe of EN523, retains binding to OTUB1 in vitro. |
| PC-72835 |
EN523
OTUB1 recruiter DUBTAC
|
EN523 (EN-523) is a small molecule covalent ligand that targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1, OTUB1 recruiter component of DUBTAC NJH-2-057. |
| PC-72699 |
MT16-001
UCHL1 inhibitor
|
MT16-001 is a selective, covalent inhibitor of deubiquitinating enzyme UCHL1 with IC50 of 580 nM, no inhibitory effect against UCHL3 (IC50>30 uM). |
| PC-72535 |
HBX-90659
USP8 inhibitor
|
HBX-90659 (compound 22 e) is a potent, selective USP8 inhibitor with IC50 of 0.28 uM, with no effect on USP7 (IC50 of >100 uM). |
| PC-72253 |
FT385
USP30 inhibitor
|
FT385 (FT3967385) is a potent, selective USP30 inhibitor with biochemical IC50 of 1.5 nM. |
| PC-72252 |
USP30 inhibitor Compound 39
USP30 inhibitor
|
USP30 inhibitor Compound 39 (CMPD-39) is a highly selective inhibitor of USP30 with IC50 of 20 nM in an in vitro assay of enzyme activity, >100-fold selectivity over other DUBs. |
