| Cat. No. |
Product Name |
Information |
| PC-24036 |
TNG348
USP1 inhibitor
|
TNG348 is a potent, a selective, allosteric and reversible USP1 inhibitor with IC50 of 98.6 nM in AlphaLISA-based measurement of ub-PCNA induction in MDA-MB-436 cells. |
| PC-23952 |
U4-I05
USP4 inhibitor
|
U4-I05 is a specific small molecule USP4 inhibitor (KD=239 nM) that inhibits USP4 deubiquitinating enzyme activity, inhibits stemness characteristics in CRC cells. |
| PC-23736 |
USP30-I-1
USP30 inhibitor
|
USP30-I-1 (USP30-IN-1) is a potent, selective and covalent inhibitor of mitochondrial deubiquitinating (DUB) enzyme USP30 with IC50 of 94 nM, shows no significant activity against other 40 endogenous DUBs. |
| PC-23143 |
IsoLiPro
USP11 inhibitor
|
IsoLiPro is a novel small molecule USP11 inhibitor, reduces the USP11 protein level and suppressesthe USP11-mediated substrate deubiquitination. |
| PC-22877 |
YCH3124
USP7 inhibitor
|
YCH3124 is a potent, selective USP7 inhibitor with IC50 of 41.9 nM and Kd of 156 nM, exhibits minimal inhibition against other USPs, including USP1, USP4, USP8, USP9X, USP15, and USP25. |
| PC-22320 |
Compound 7695-0983
FAT10 inhibitor
|
Compound 7695-0983 is a small molecule inhibitor of HLA-F locus-adjacent transcript 10 (FAT10), inhibits the expression of FAT10, inhibits NEDD4-PTEN/AKT axis-mediated autophagy. |
| PC-22313 |
USP10 inhibitor D1
USP10 inhibitor
|
USP10 inhibitor D1 is a potent, selective small molecule ubiquitin-specific protease 10 (USP10) inhibitor with IC50 of 7.2 uM, KD of 5.24 uM in microscale thermophoresis (MST)-based binding assay. |
| PC-22261 |
CT1113
USP28 inhibitor
|
CT1113 is a potent, selective small molecule USP25/USP28 inhibitor with IC50 of 26.1 nM/3.9 nM, respectively. |
| PC-22260 |
FX1-5303
USP7 inhibitor
|
FX1-5303 is a highly potent, specific ubiquitin-specific protease 7 (USP7) inhibitor with biochemical IC50 of 0.29 nM. |
| PC-22183 |
Vialinin A
USP4/USP5 inhibitor
|
Vialinin A (Terrestrin A) is a p-terphenyl compound with antioxidant properties, inhibits the peptidase activity of USP5/IsoT with IC50 of 5.9 uM, also inhibits the enzymatic activities of USP4 with IC50 of 1.5 uM. |
| PC-21919 |
LLK203
USP2/USP8 inhibitor
|
LLK203 is a potent, dual-targeting USP2/USP8 inhibitor with IC50 of 0.89/0.52 uM, potently inhibits cell proliferation of MCF-7 breast cancer cells with IC50 of 3.4 uM. |
| PC-21918 |
PCR-6236
USP2/USP8 inhibitor
|
PCR-6236 is a potent dual-targeting USP2/USP8 inhibitor with IC50 of <0.1/0.8 uM, respectively. |
