| Cat. No. |
Product Name |
Information |
| PC-20185 |
IU2-6
USP14 inhibitor
|
IU2-6 is a small molecule USP14 inhibitor, shows 74% inhibition at 8 uM. |
| PC-20184 |
GSK2643943A
USP20 inhibitor
|
GSK2643943A is a specific, cell penetrant small molecule inhibitor of deubiquitinating enzyme USP20 with IC50 of 160 nM (USP20/Ub-Rho). |
| PC-20004 |
TG2-179-1
BAP1 inhibitor
|
TG2-179-1 is a potent, selective and covalently inhibitor of deubiquitinase (DUB) BRCA1-associated protein-1 (BAP1), covalently binds to the active site of BAP1 (Cys91), exhibits potent cytotoxic activity against colon cancer cells. |
| PC-20001 |
CAS-12290-201
VCPIP1 inhibitor
|
CAS-12290-201 is a potent and selective inhibitor of deubiquitinating enzyme (DUB) VCPIP1 with IC50 of 70 nM, covalently and specificly targets the catalytic cysteine of VCPIP1 with little to no activity toward other cellular DUBs. |
| PC-49863 |
BAY-728
BAY-805 negative control
|
BAY-728 (BAY728, (S)-BAY-805) is a less potent enantiomer and negative control compound of BAY-805, which is a potent and selective Inhibitor of USP21. |
| PC-49862 |
BAY-805
USP21 inhibitor
|
BAY-805 (BAY805) is the first highly potent, selective and non-covalent USP21 inhibitor with IC50 of 6 nM and 2 nM in HTRF and Ub-rhodamine biochemical assays (hUSP21), respectively. |
| PC-49744 |
BML-260
JSP-1 (DUSP22) inhibitor
|
BML-260 (BML260) is a potent inhibitor of dual-specific phosphatase JSP-1 (JNK Stimulatory Phosphatase-1, DUSP22) and stimulator of uncoupling protein 1 (UCP-1) expression in adipocytes. |
| PC-49689 |
I-138
UPS1 inhibitor
|
I-138 (I 138) is a potent, specific small molecule USP1-UAF1 inhibitor with IC50 of 4.1 nM, binds to USP1-UAF1 at an allosteric pocket synergistically with ubiquitin. |
| PC-49626 |
8RK64
UCHL1 inhibitor
|
8RK64 is a covalent small molecule inhibitor of ubiquitin carboxy-terminal hydrolase L1 (UCHL1, PGP9.5, PARK5) enzyme with IC50 of 0.32 uM, >80-fold selectivity over UCHL3 and UCHL5. |
| PC-49546 |
Usp22i-S02
USP22 inhibitor
|
Usp22i-S02 (Usp22 inhibitor S02) is a specific small-molecule inhibitor of the Foxp3-specific deubiquitinase USP22, down-regulates Foxp3 expression in Treg cells in a Usp22- but not Usp21-dependent manner. |
| PC-49371 |
GK13S
UCHL1 inhibitor
|
GK13S is a highly potent, specific and covalent inhibitor of deubiquitinase UCHL1 with IC50 of 87 nM, displays exquisite specificity for UCHL1 over the other UCH family members (IC50>10 uM). |
| PC-49051 |
DC-U4106
USP8 inhibitor
|
DC-U4106 is a potent, selective small molecule inhibitor of Ubiquitin-specific protease 8 (USP8) with binding KD value of 4.7 uM, DC-U4106 is selective over USP2 and USP7. |
