| Cat. No. |
Product Name |
Information |
| PC-25366 |
CAS-010
USP28 inhibitor
|
CAS-010 (CAS-13312-010) is a potent, selective and ubiquitin-competitive inhibitor of USP28 with IC50 of 4.2 nM in UbRho assays, disrupts the 53BP1-USP28 interaction and reduces p53 target gene transactivation. |
| PC-25113 |
USP14 inhibitor AKOS
USP14 inhibitor
|
USP14 inhibitor AKOS (AKOSB018304) is a specific and covalent USP14 inhibitor with IC50 of 0.98 uM for USP14 deubiquitinase activity, also is a small molecule chikungunya virus (CHIKV) inhibitor. |
| PC-24867 |
Mitoxantrone
USP11 inhibitor
|
Mitoxantrone is a specific small molecule inhibitor of USP11 with IC50 of 3.15 uM, impacts PDA cell survival with an IC50<10 nM, also is a potent topoisomerase II inhibitor and inhibits protein kinase C (PKC) activity with IC50 of 8.5 uM. |
| PC-24713 |
USP24-i-101
USP24 inhibitor
|
USP24-i-101 (Compound 677-8) is a specific small molecule inhibitor of USP24, induces autophagy in interphase and mitosis by inhibiting E2F4 and TRAF6, respectively. |
| PC-24549 |
TNG-6132
USP1 inhibitor
|
TNG-6132 is a potent, selective, reversible, allosteric and orally bioavailable USP1 inhibitor with pIC50 of 7.9 (USP1-UAF1 complex), and pIC50 of 7.6 in cellular viability assay with MDA-MB-436 cells. |
| PC-24536 |
NK036
USP30 inhibitor
|
NK036 is a solubility-enhanced derivative of USP30 inhibitor Compound 39 (CMPD-39), has IC50 of 7.4 nM and 4.1 nM for human USP30 (construct 1 (c1) and USP ch3, respectively. |
| PC-24036 |
TNG348
USP1 inhibitor
|
TNG348 is a potent, a selective, allosteric and reversible USP1 inhibitor with IC50 of 98.6 nM in AlphaLISA-based measurement of ub-PCNA induction in MDA-MB-436 cells. |
| PC-23952 |
U4-I05
USP4 inhibitor
|
U4-I05 is a specific small molecule USP4 inhibitor (KD=239 nM) that inhibits USP4 deubiquitinating enzyme activity, inhibits stemness characteristics in CRC cells. |
| PC-23862 |
USP30i-3
USP30 inhibitor
|
USP30i-3 is a potent, selective small molecule USP30 inhibitor with IC50 of 21 nM, selective over other DUBs (IC50=250->3000 nM) with exception of USP6 (IC50=60 nM). |
| PC-23861 |
USP30i-37
USP30 inhibitor
|
USP30i-37 is a potent, selective small molecule USP30 inhibitor with IC50 of 48 nM, selective over other DUBs (IC50=400->3000 nM) with exception of USP6 (IC50=95 nM). |
| PC-23736 |
USP30-I-1
USP30 inhibitor
|
USP30-I-1 (USP30-IN-1) is a potent, selective and covalent inhibitor of mitochondrial deubiquitinating (DUB) enzyme USP30 with IC50 of 94 nM, shows no significant activity against other 40 endogenous DUBs. |
| PC-23143 |
IsoLiPro
USP11 inhibitor
|
IsoLiPro is a novel small molecule USP11 inhibitor, reduces the USP11 protein level and suppressesthe USP11-mediated substrate deubiquitination. |
