| Cat. No. |
Product Name |
Information |
| PC-26656 |
Berberine chloride hydrate
USP22 inhibitor
|
Berberine chloride hydrate (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, disrupts G-quadruplex (G4)-STAT1 interaction and synergizes with olaparib to drive cancer cell death, shows antineoplastic properties, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation. |
| PC-26655 |
Berberine
USP22 inhibitor
|
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, disrupts G-quadruplex (G4)-STAT1 interaction and synergizes with olaparib to drive cancer cell death, shows antineoplastic properties, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation |
| PC-26500 |
WEHI-092
USP9X inhibitor
|
WEHI-092 is a potent and selective inhibitor of USP9X with IC50 of 254 nM, directly binds to USP9X catalytic domain with SPR KD of 1 uM, does not inhibit USP24 and other DUBs. |
| PC-26479 |
P6620
USP7 inhibitor
|
P6620 is a specific small molecule inhibitor USP7, effectively inhibits the USP7/LRRC41 axis to suppress HCC malignancy. |
| PC-26283 |
UC495
OTULIN inhibitor
|
UC495 is a specific small molecule inhibitor of deubiquitinase OTULIN, interacts with the OTULIN deubiquitinase binding pocket. |
| PC-26236 |
USP11 inhibitor 26
USP11 inhibitor
|
USP11 inhibitor 26 (USP11-IN-1) is a selective inhibitor of USP11 with IC50 of 10.9 uM, shows 1.7- and >100-fold selective over USP4 and USP15. |
| PC-26235 |
USP11 inhibitor 7
USP11 inhibitor
|
USP11 inhibitor 7 (USP11-IN-2) is a selective inhibitor of USP11 with IC50 of 2.6 uM, shows >30- and 100-fold selective over USP4 and USP15. |
| PC-26201 |
WWQ-03-012
DESI2 inhibitor
|
WWQ-03-012 is a potent, specific and covalent inhibitor of JAK2‐V617F complex component DESI2 with IC50 of 47.3 nM, selectively degrades mutant JAK2. |
| PC-25571 |
OAT-4828 dihydrochloride
USP7 inhibitor
|
OAT-4828 dihydrochloride is a potent, and selective USP7 inhibitor with IC50 of 22 nM in enzymatic assay and 33 nM in reporter assay (Ub-CHOP reporter system). |
| PC-25550 |
USP19-IN-1
USP19 inhibitor
|
USP19-IN-1 (Example 124) is a potent, selective USP19 inhibitor with IC50 of <0.5 uM, high selective against a panel of 24 USPs and 19 other DUBs. |
| PC-25142 |
USP10 inhibitor LY-2
USP10 inhibitor
|
USP10 inhibitor LY-2 is a potent ubiquitin-specific protease 10 (USP10) inhibitor with SPR binding KD of 365 nM and IC50 of 10.87 uM. |
| PC-24885 |
Hyperoside
USP18 inhibitor
|
Hyperoside is a naturally occurring flavonol glycoside with anti-colitis and anticancer potential, also is a USP18 inhibitor that directly targets the USP18 IBB1 domain (BLI KD=7.04 uM), hyperoside inhibits PRRSV proliferation via the TLR4/NF-kappaB and p62-Nrf2-Keap1 signaling pathways. |
