Catalog No.: PC-22864Not For Human Use, Lab Use Only.
USP1 inhibitor C527 is a specific small-molecule inhibitor of USP1 blocking the deubiquitinating enzyme activity of USP1 with IC50 of 0.88 uM (USP/UAF1 complex).
USP1 inhibitor C527 is a specific small-molecule inhibitor of USP1 blocking the deubiquitinating enzyme activity of USP1 with IC50 of 0.88 uM (USP/UAF1 complex). C527 shows less inhibitory effect on UCH-L1 and UCH-L3, inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro with higher IC50 values. C527 promoted the dose-dependent degradation of ID1 in human U20S osteosarcoma cells.
Physicochemical Properties
M.Wt
293.25
Formula
C17H8FNO3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
References
1. Helena Mistry, et al. Mol Cancer Ther. 2013 Dec;12(12):2651-62.
