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Chemical Structure : USP1 inhibitor C527
CAS No.: 192718-06-2
Catalog No.: PC-22864Not For Human Use, Lab Use Only.
USP1 inhibitor C527 is a specific small-molecule inhibitor of USP1 blocking the deubiquitinating enzyme activity of USP1 with IC50 of 0.88 uM (USP/UAF1 complex).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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USP1 inhibitor C527 is a specific small-molecule inhibitor of USP1 blocking the deubiquitinating enzyme activity of USP1 with IC50 of 0.88 uM (USP/UAF1 complex).
C527 shows less inhibitory effect on UCH-L1 and UCH-L3, inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro with higher IC50 values.
C527 promoted the dose-dependent degradation of ID1 in human U20S osteosarcoma cells.
| M.Wt | 293.25 | |
| Formula | C17H8FNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione |
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1. Helena Mistry, et al. Mol Cancer Ther. 2013 Dec;12(12):2651-62.
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