| Cat. No. |
Product Name |
Information |
| PC-23293 |
SN-407
LRRC8 inhibitor
|
SN-407 is a potent Volume-Regulated Anion Channel (VRAC) inhibitor with IC50 of 1.6 uM in HEK cells, targets LRRC8 complex and blocks agonist-induced aggregation, ATP release, and calcium influx in platelets. |
| PC-21384 |
CBD3063
CaV2.2 inhibitor
|
CBD3063 is a selective, first-in-class inhibitor of Cav2.2-CRMP2 (ollapsin response mediator protein 2) interaction, suppresses surface trafficking of Cav2.2, and N-type (Cav2.2) calcium currents. |
| PC-20398 |
Rynaxypyr
RyR activator
|
Rynaxypyr (Chlorantraniliprole) is a highly potent and selective activator of insect ryanodine receptors (Hv RyR EC50=52 nM) with exceptional activity on a broad range of Lepidoptera. |
| PC-20397 |
RyR2 inhibitor EL9
RyR2 inhibitor
|
RyR2 inhibitor EL9 is a potent mutant RyR2 channel inhibitor, inhibits Ca2+ spark frequency (CaSF) in R176Q/+ myocytes with IC50 of 13 nM. |
| PC-20396 |
RyR2 inhibitor EL20
RyR2 inhibitor
|
RyR2 inhibitor EL20 is a potent antiarrhythmic compound, potently inhibits abnormal Ca2+ release in RyR2 R176Q myocytes with IC50 of 35.4 nM. |
| PC-20395 |
Cyantraniliprole
RyR activator
|
Cyantraniliprole (DPX-HGW86) is an insecticide of the ryanoid class, is a potent and selective anthranilic diamide ryanodine receptor (RyR) activator (Dipteran RyR, EC50=0.9 uM). |
| PC-20121 |
IPPQ
CaV2.2 inhibitor
|
IPPQ is a small molecule that selectively target the interface between the N-type calcium (CaV2.2) channel and CaVβ, specifically binds to CaVβ2a and inhibits CaVβ2's interaction with CaV.2-AID (alpha interacting domain). |
| PC-49748 |
HSK16149
VGCC α2δ ligand
|
HSK16149 (Crisugabalin) is a potent selective ligand of voltage-gated calcium channel (VGCC) α2δ subunit with IC50 of 3.96 nM in competitive [3H]gabapentin binding assays. |
| PC-49733 |
PST3093
SERCA2a activator
|
PST3093 (PST 3093) is the main Istaroxime metabolite and a selective SERCA2a activator, reduces the SERCA2a KdCa value by about 20% at 100 nM. |
| PC-49732 |
Istaroxime hydrochloride
Na-K ATPase inhibitor
|
Istaroxime (PST2744) is an inotropic agent and Na(+)/K(+)-ATPase inhibitor, inhibits dog kidney Na(+)/K(+)-ATPase with IC50 of 0.43 uM, also stimulates SERCA2a. |
| PC-49242 |
TPC2-A1-P
TPC2 agonist
|
TPC2-A1-P is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 10.5 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium. |
| PC-49241 |
TPC2-A1-N
TPC2 agonist
|
TPC2-A1-N is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 7.8 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium. |
