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RyR2 inhibitor EL20

Chemical Structure : RyR2 inhibitor EL20

CAS No.: 714906-29-3

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RyR2 inhibitor EL20

Catalog No.: PC-20396Not For Human Use, Lab Use Only.

RyR2 inhibitor EL20 is a potent antiarrhythmic compound, potently inhibits abnormal Ca2+ release in RyR2 R176Q myocytes with IC50 of 35.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RyR2 inhibitor EL20 is a potent antiarrhythmic compound, potently inhibits abnormal Ca2+ release in RyR2 R176Q myocytes with IC50 of 35.4 nM.
    EL20 inhibits single-channel activity of purified RyR2 occurs in RyR2 R176Q myocytes with IC50 of 8.2 nM.
    EL20 (2.5 µg/kg, i.p.) suppresses the induction of ventricular tachycardia (VT) in R176Q mice.
    EL20 only inhibited RyR2 single-channels in the absence of the stabilizing protein calmodulin.

    Physicochemical Properties

    M.Wt 322.45
    Formula C18H30N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(diethylamino)ethyl 4-(butylamino)-2-methoxybenzoate

    References

    1. Robert C Klipp, et al. Heart Rhythm. 2018 Apr;15(4):578-586.

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