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Chemical Structure : RyR2 inhibitor EL20
Catalog No.: PC-20396Not For Human Use, Lab Use Only.
RyR2 inhibitor EL20 is a potent antiarrhythmic compound, potently inhibits abnormal Ca2+ release in RyR2 R176Q myocytes with IC50 of 35.4 nM.
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RyR2 inhibitor EL20 is a potent antiarrhythmic compound, potently inhibits abnormal Ca2+ release in RyR2 R176Q myocytes with IC50 of 35.4 nM.
EL20 inhibits single-channel activity of purified RyR2 occurs in RyR2 R176Q myocytes with IC50 of 8.2 nM.
EL20 (2.5 µg/kg, i.p.) suppresses the induction of ventricular tachycardia (VT) in R176Q mice.
EL20 only inhibited RyR2 single-channels in the absence of the stabilizing protein calmodulin.
| M.Wt | 322.45 | |
| Formula | C18H30N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Robert C Klipp, et al. Heart Rhythm. 2018 Apr;15(4):578-586.
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