| Cat. No. |
Product Name |
Information |
| PC-23202 |
CHIR-090
LpxC inhibitor
|
CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria. |
| PC-22658 |
KSP-1007
β-lactamase inhibitor
|
KSP-1007 is a potent, broad-spectrum boronic acid β-lactamase inhibitor, strongly inhibits class A carbapenemase KPCs with Ki app values of 0.836-2.19 nM, inhibits all β-lactamases from classes A, B, C, and D, enhances meropenem against carbapenem-resistant Gram-negative bacteria. |
| PC-22472 |
BTZ043
DprE1 inhibitor
|
BTZ043 is a small molecule antimycobacterial agent taregting the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase, shows MIC values of 1 ng/ml (2.3 nM) and 4 ng/ml (9.2 nM) against M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively. |
| PC-22468 |
Lolamicin
LolCDE inhibitor
|
Lolamicin is a Gram-negative-specific antibiotic targeting the lipoprotein transport system LolCDE complex, shows potent activity in against Gram-negative pathogens, sparing the gut microbiome. |
| PC-22410 |
Lefamulin
Antibiotic
|
Lefamulin (BC-3781) is a pleuromutilin class of antimicrobial agent, inhibits bacterial protein synthesis by selectively binding to the peptidyl transferase center of the bacterial ribosome, prevents the correct positioning of the 3′-CCA ends of tRNAs for peptide transfer. |
| PC-22409 |
Lefamulin acetate
Antibiotic
|
Lefamulin (BC-3781) acetate is a pleuromutilin class of antimicrobial agent, inhibits bacterial protein synthesis by selectively binding to the peptidyl transferase center of the bacterial ribosome, prevents the correct positioning of the 3′-CCA ends of tRNAs for peptide transfer. |
| PC-22350 |
Cadazolid
Antibiotic
|
Cadazolid (ACT-179811) is a first-in-class quinoxolidinone antibiotic and a potent inhibitor of C. difficile protein synthesis with IC50 of 0.38 uM in in vitro transcription/translation assay, MIC of <0.03 ug/mL against Clostridioides difficile ATCC 700057. |
| PC-22101 |
IITR08367
Efflux pump AbaF inhibitor
|
IITR08367 is a potent efflux inhibitor against AbaF in A. baumannii, inhibits efflux pumps by disrupting the proton gradient across the bacterial membrane. |
| PC-21689 |
BDM91288
AcrB efflux pump inhibitor
|
BDM91288 is a pyridylpiperazine-based AcrB efflux pump inhibitor, potentiates the activity of a panel of antibiotics against K. pneumoniae. |
| PC-21552 |
SMT-738
LolCDE inhibitor
|
SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity. |
| PC-21546 |
SQ109
Mtb MmpL3 inhibitor
|
SQ109 (NSC 722041) is an ethambutol (EMB) analog and antitubercular agent targeting MmpL3, shows MICs of 1-0.5 uM. |
| PC-20744 |
MAC13772
Biotin biosynthesis inhibitor
|
MAC13772 is a small molecule inhibitor of bacterial enzyme BioA with IC50 of 250 nM, the antepenultimate step in biotin biosynthesis, MAC13772 inhibits biotin biosynthesis. |
