Chemical Structure : FBX-1991
CAS No.:
FBX-1991
(FBX1991)
Catalog No.: PC-24236Not For Human Use, Lab Use Only.
FBX-1991 is a potent, specific small molecule inhibitor of Helicobacter pylori (H. pylori) dehydrogenase/isomerase FabX with IC50 of 0.158 uM, shows potent antibacterial activity against strain BHKS211 with MIC of 16 ug/mL.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FBX-1991 is a potent, specific small molecule inhibitor of Helicobacter pylori (H. pylori) dehydrogenase/isomerase FabX with IC50 of 0.158 uM, shows potent antibacterial activity against strain BHKS211 with MIC of 16 ug/mL.
FabX is essential for H. pylori growth and gastric colonization by retaining UFA synthesis and producing ROS, respectively, and is a species-specific anti-H. pylori drug target.
FBX-1991 does not inhibit the enzymatic activities of the structurally conserved homolog FabK.
FBX-1991 significantly inhibits the growth of H. pylori strain G27 and three clinical drug-resistant isolates with MIC of 16 ug/mL, but does not inhibit the growth of the non-Helicobacter strains at 128 ug/mL.
FBX-1991 partially inhibits UFA and cyclopropane fatty acid synthesis, ROS production and subsequent excretion from H. pylori by specifically targeting FabX in vivo.
Physicochemical Properties
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M.Wt
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452.31
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Formula
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C19H15Cl2N3O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl 3-((2-((2,4-dichlorophenyl)amino)pyridine)-3-sulfonamido)benzoate
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References
1. Zhang L, et al. Adv Sci (Weinh). 2025 Mar 16:e2414844.
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