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Cat. No. Product Name Information
PC-22002

DNL343

eIF2B activator

DNL343 is a potent, selective, and brain-penetrant eIF2B activator with IC50 of 3.2 nM in cellular ATF4 nano-Luciferase (nLuc) reporter assays.
PC-22001

ABBV-CLS-7262

eIF2B activator

ABBV-CLS-7262 (Fosigotifator) is a potent, selective eIF2B activator undergoing clinical development for ALS and vanishing white matter disease.
PC-21794

eEF2K degrader C1

eEF2K inhibitor

eEF2K degrader C1 is a small-molecule degrader of eEF2K, acts a molecular glue to enhance the interaction of eEF2K with the ubiquitin E3 ligase βTRCP, thereby promoting the proteasomal degradation of eEF2K.
PC-21688

MG-002

eIF4A inhibitor

MG-002 is a potent, second-generation, orally bioavailable eIF4A RNA helicase inhibitor, potently inhibits cap-dependent mRNA translation with IC50 of 43 nM.
PC-21264

Briciclib

eIF4E inhibitor

Briciclib (ON 014185) is a small molecule inhibitor of eukaryotic translation initiation factor 4E (eIF4E), downregulates the expression of eIF4E and its two complex partners eIF4A and G, as well as other eIFs (e.g. eIF1A, eIF2α, eIF3A, eIF3B, eIF5 and eIF6).
PC-20686

SBI-0498

eIF4F inhibitor

SBI-0498 (SBI-0730498) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels.
PC-20685

SBI-5844

eIF4F inhibitor

SBI-5844 (SBI-1275844) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels.
PC-20483

eIF4E-RBM38 inhibitor 094

eIF4E-RBM38 inhibitor

eIF4E-RBM38 inhibitor 094 (Compound 094) is a first-in-class small molecule inhibitor of eIF4E-RBM38 complex, binds to eIF4E via its C-terminus pocket (Kd=16 uM) and dissociates RBM38 from eIF4E, enhances p53 translation in RBM38- and eIF4E-dependent manners.
PC-49309

RBF197

eIF4A inhibitor

RBF197 (RBF-197) is a novel highly potent and selective eIF4A inhibitor, inhibits human eIF4A helicase activity with IC50 of 55.2 pM.
PC-49308

eIF4A inhibitor 28

eIF4A inhibitor

eIF4A inhibitor 28 (eIF4A-IN-28) is a novel small molecule RNA-competitive, ATP-uncompetitive inhibitor of eIF4A, inhibits eIF4A ATPase and helicase activities with IC50 of 8.6 and 6.6 uM, respectively.
PC-72482

Rohinitib

eIF4A1 inhibitor

Rohinitib is a potent and specific inhibitor of eIF4A1, inhibits growth and survival of AML cells especially cells with FLT3-ITD.
PC-72234

EGPI-1

eIF4E/eIF4G inhibitor

EGPI-1 is a potent small molecule that inhibits the translation initiation factors eIF4E/eIF4G interaction.

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