| Cat. No. |
Product Name |
Information |
| PC-26557 |
PF-07293623
eIF4E inhibitor
|
PF-07293623 is a first-in-class, specific eukaryotic initiation factor 4E (eIF4E) cap-binding domain inhibitor, inhibits protein synthesis and disrupts eIF4E binding to the m7G cap. |
| PC-25745 |
EJC-i
EJC inhibitor, eIF4A3 inhibitor
|
EJC-i (eIF4A3 inhibitor 18, Exon Junction Complex inhibitor) is a selective ATP-competitive eIF4A3 ATPase inhibitor with IC50 of 0.97 uM and SPR KD of 0.2 uM, has excellent selectivity over other helicases, inhibits de novo Exon Junction Complex (EJC) assembly. |
| PC-24998 |
IBX-200
ISR modulator, GCN2 inhibitor
|
IBX-200 is a selective integrated stress response (ISR) modulator targeting stress sensor kinase GCN2, selectively eliminates ISR-high cells across diverse stressors. |
| PC-24689 |
1Ai-3638
eIF1A inhibitor
|
1Ai-3638 is a small molecule binder of eIF1A, blocks RPS10-eIF1A interaction and inhibits eIF1A association with the 48S in vitro and in cells. |
| PC-23755 |
Girolline
eIF5A modulator
|
Girolline (Girodazole) is a sequence-selective modulator of translation factor eIF5A, interferes with ribosome-eIF5A interaction and induces ribosome stalling, an anti-tumor agent as well as having activity against malaria. |
| PC-22966 |
eEF2K Degrader 36
eEF2K degrader
|
eEF2K Degrader 36 is a potent eEF2K degrader with binding KD of 330 nM, DC50 of 319 nM in MDA-MB-231 cells. |
| PC-22415 |
CR-1-31-B
eIF4A inhibitor
|
CR-1-31-B (CR-31) is a potent and specific eIF4A RNA helicase inhibitor, blocks translation of the MUC1-C oncoprotein. |
| PC-22002 |
DNL343
eIF2B activator
|
Evetifator (DNL343) is a potent, selective, and brain-penetrant eIF2B activator with IC50 of 3.2 nM in cellular ATF4 nano-Luciferase (nLuc) reporter assays. |
| PC-22001 |
ABBV-CLS-7262
eIF2B activator
|
ABBV-CLS-7262 (Fosigotifator) is a potent, selective eIF2B activator undergoing clinical development for ALS and vanishing white matter disease. |
| PC-21794 |
eEF2K degrader C1
eEF2K inhibitor
|
eEF2K degrader C1 is a small-molecule degrader of eEF2K, acts a molecular glue to enhance the interaction of eEF2K with the ubiquitin E3 ligase βTRCP, thereby promoting the proteasomal degradation of eEF2K. |
| PC-21728 |
Plitidepsin
eEF1A inhibitor
|
Plitidepsin (Aplidine, PM90001) is a potent anti-cancer agent by targeting eEF1A2 with KD value of 80 nM, shows antiviral activity against SARS-CoV-2 with IC90 of 0.88 nM. |
| PC-21688 |
MG-002
eIF4A inhibitor
|
MG-002 is a potent, second-generation, orally bioavailable eIF4A RNA helicase inhibitor, potently inhibits cap-dependent mRNA translation with IC50 of 43 nM. |
