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1Ai-3638

Chemical Structure : 1Ai-3638

CAS No.: 883012-32-6

1Ai-3638

Catalog No.: PC-24689Not For Human Use, Lab Use Only.

1Ai-3638 is a small molecule binder of eIF1A, blocks RPS10-eIF1A interaction and inhibits eIF1A association with the 48S in vitro and in cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

1Ai-3638 is a small molecule binder of eIF1A, blocks RPS10-eIF1A interaction and inhibits eIF1A association with the 48S in vitro and in cells.
1Ai-3638 decreases the development of ovarian cancer in OVCAR8 cell-derived xenograft (CDX) model.

Physicochemical Properties

M.Wt 444.97
Formula C23H25ClN2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-(N-(adamantan-1-yl)sulfamoyl)phenyl)-4-chlorobenzamide

References

1. Hayat D, et al. EMBO J. 2025 May 12. doi: 10.1038/s44318-025-00449-6.

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