| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-72469 |
GNE-9815
|
2729996-45-4 |
GNE-9815 (GNE9815) is a potent, selective, oral Type II pan-RAF inhibitor with Ki of 0.062 and 0.19 nM for CRAF and BRAF, respectively. |
| PC-72243 |
BRAF inhibitor Compound Ia
|
2649372-20-1 |
BRAF inhibitor Compound Ia is a potent, selective, brain penetrant BRAF inhibitor with binding Kd of 0.6, 1.2, and 1.7 nM for BRAF WT, BRAF V600E, and c-RAF, presenting paradox breaker properties. |
| PC-35635 |
LXH254
|
1800398-38-2 |
LXH254 (Naporafenib, LXH 254) is a highly potent, selective B/C RAF inhibitor with Kd of 1.3/3.6 nM respectively, shows less activity against ARAF. |
| PC-42871 |
Vemurafenib
|
918504-65-1 |
Vemurafenib (PLX-4032, RG7204, RO5185426) is a potent, selective B-RAF V600E inhibitor with IC50 of 30 nM, displays similar potency for c-RAF-1 (IC50=48 nM), and has selectivity against many other kinases, including wild type B-RAF (IC50=100nM). |
| PC-63027 |
SB-699393
|
1348166-93-7 |
SB-699393 is a potent, selective and CNS penetrant B-Raf inhibitor with Kd of 7.2 nM. |
| PC-61364 |
Belvarafenib
|
1446113-23-0 |
Belvarafenib (HM95573, GDC5573) is a novel potent, selective RAF inhibitor with IC50 of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF V600E and CRAF, respectively. |
| PC-45573 |
BGB-283
|
1446090-77-2 |
BGB-283 (Lifirafenib, BGB283) is a potent pan RAF inhibitor of BRAF V600E, wt BRAF, CRAFY340/341D and wt ARAF (IC50=5-40 nM). |
