LF-268 | pan-Raf inhibitor | Probechem Biochemicals

Chemical Structure : LF-268

Catalog No.: PC-26817Not For Human Use, Lab Use Only.

LF-268 is a potent, selective pan-RAF inhibitor with IC50 of 3.9 nM, 4.0 nM and 1.0 nM for A-Raf, B-Raf and C-Raf respectively.

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Biological Activity

LF-268 is a potent, selective pan-RAF inhibitor with IC50 of 3.9 nM, 4.0 nM and 1.0 nM for A-Raf, B-Raf and C-Raf respectively.

M.Wt	545.52
Formula	C29H22F3N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((7-(2-methoxyethyl)-6-(oxazol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethynyl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

1. Stoddard EG, et al. Nat Chem Biol. 2026 May 12. doi: 10.1038/s41589-026-02212-2.