| Cat. No. |
Product Name |
Information |
| PC-21435 |
SM04755
CLK inhibitor
|
Teplinovivint (SM04755) is a small molecule canonical Wnt signaling inhibitor, potently inhibited CLK2, CLK3, and DYRK1A with IC50 of 5.0 nM, 48.6 nM and 3.5 nM, respectively. |
| PC-20474 |
GPS192
CLK inhibitor
|
GPS192 (GPS 167) is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A. |
| PC-73374 |
CLK4 inhibitor 96
CLK4 inhibitor
|
CLK4 inhibitor 96 is a novel potent CLK4 inhibitor with IC50 of 57.5 nM. |
| PC-73373 |
GPS167
CLK inhibitor, SRSF10 inhibitor
|
GPS167 is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A. |
| PC-72906 |
Ipivivint
CLK inhibitor
|
Ipivivint is a potent, selective CLK inhibitor, inhibits Wnt pathway signaling gene expression through inhibiting CLK activity and serine and SRSF phosphorylation. |
| PC-72778 |
TG003
CLK inhibitor
|
TG003 (TG-003) is a potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (CLK) with IC50 of 20, 200 and 15 nM for mClk1, 2 and 4 respectively, and >10 uM for mClk3 |
| PC-72581 |
CaNDY
CLK inhibitor
|
CaNDY is a highly potent rectifier of the aberrant splicing, potently inhibits DYRK1A, DYRK1B, CLK1/CLK2/ with IC50 of 21.6/68.3/116 nM in in vitro kinase assays. |
| PC-72099 |
Cirtuvivint
CLK inhibitor
|
Cirtuvivint (SM08502) is a novel potent, selective inhibitor of CDC-like kinase (CLK) with IC50 of 2/22 nM against CLK2/3. |
| PC-35987 |
MU1210
CLK inhibitor
|
MU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM (cellular BRET for CLK1). |
| PC-35359 |
CLK2 inhibitor Indazole 1
CLK2 inhibitor
|
CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases. |
| PC-35047 |
T-025
CLK inhibitor
|
T-025 (T025, CLK inhibitor T-025) is an orally available, potent inhibitor of Cdc2-like kinases (CLKs) with Kd of 4.8, 0.096, 6.5, and 0.61 nM for CLK1, CLK2, CLK3, and CLK4, also inhibits DYRK1A and DYRK1B with IC50 of 0.074 and 1.5 nM. |
| PC-63478 |
Leucettamine B
CLK1 inhibitor
|
Leucettamine B is a potent inhibitor of CLK1 (IC50=15 nM), Dyrk1A (IC50=40 nM), and Dyrk2 (IC50=35 nM) and a moderate inhibitor of CLK3 (IC50=4.5 uM).. |
