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Chemical Structure : GPS192
Catalog No.: PC-20474Not For Human Use, Lab Use Only.
GPS192 (GPS 167) is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A.
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GPS192 (GPS 167) is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A.
GPS192 promotes the dephoshorylation of SRSF10 and changes its interaction with partner proteins.
GPS192 treatment leads to a partial dephosphorylation of SRSF10 and increases the recovery of CLK1 and CLK4.
GPS192 impairs the growth of cancer cell line, elicits p53-dependent cytotoxicity.
| M.Wt | 392.46 | |
| Formula | C18H12N6OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Muhammad Sohail, et al. NAR Cancer. 2021 May 25;3(2):zcab019.
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