| Cat. No. |
Product Name |
Information |
| PC-21622 |
Fulvestrant
ER inhibitor
|
Fulvestrant (ICI 182780) is a steroidal antiestrogen, and potent, specific estrogen receptor (ER) antagonist with IC50 of 0.94 nM. |
| PC-21173 |
Raloxifene
SERM
|
Raloxifene (Keoxifene, LY139481) is potent, selective estrogen receptor modulator (SERM). |
| PC-21008 |
CIDD-0149897
ERβ agonist
|
CIDD-0149897 is a potent, selective, brain permeable estrogen receptor beta (ERβ) agonist, 40-fold selective over ERα. |
| PC-20982 |
SLU-PP-915
ERR agonist
|
SLU-PP-915 is a potent pan-ERR (Estrogen-related receptor) nuclear receptor agonist with EC50 of 414/435/378 nM for ERRα/ERRβ/ERRγ, respectively. |
| PC-20547 |
Palazestrant
ER antagonist
|
Palazestrant (OP-1250) is a potent, orally bioavailable complete estrogen receptor (ER) antagonist (IC50=6.4 nM) and selective ER degrader, blocks activity of both AF1 and AF2. |
| PC-20417 |
SLU-PP-1072
ERRα/γ inverse agonist
|
SLU-PP-1072 is a potent, selective, dual ERRα/γ inverse agonist, inhibits ERRα- and ERRγ-dependent transcription in cotransfection assays with IC50 of 4.8 and 0.9 uM. |
| PC-20416 |
SLU-PP-332
ERR agonist
|
SLU-PP-332 is a potent, selective pan ERRα/β/γ agonist with EC50 of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, in full-length ERR cell-based cotransfection/reporter assays. |
| PC-20415 |
GSK4716
ERRβ/γ agonist
|
GSK4716 (GSK 4716) is a selective agonist of estrogen-related receptors ERRβ and ERRγ with EC50 of 1.3 uM (ERRγ). |
| PC-20414 |
DY131
ERRβ/γ agonist
|
DY131 (GSK 9089) is a selective agonist of the ERRβ/γ receptor with EC50 of 130 nM, does not affect the ERRα, ERα and β (IC50>30 uM). |
| PC-49259 |
SMIP34
PELP1 inhibitor
|
SMIP34 (Small Molecule Inhibitor of PELP1 34) is a first-in-class, small molecule inhibitor of estrogen receptor (ER) coregulator PELP1, binds to (Kd=37.4 uM) and reduces PELP1 oncogenic functions. |
| PC-49172 |
H3B-6545 hydrochloride
ERα antagonist
|
H3B-6545 hydrochloride is a potent, covalent antagonist of both wild-type and mutant estrogen receptor alpha (ERα), shows antiproliferative activity for ERαWT and ERαY537S overexpressing MCF7 cells with or without H524 L ESR1 mutation with low nM IC50 values. |
| PC-49171 |
H3B-6545
ERα antagonist
|
H3B-6545 is a potent, covalent antagonist of both wild-type and mutant estrogen receptor alpha (ERα), shows antiproliferative activity for ERαWT and ERαY537S overexpressing MCF7 cells with or without H524 L ESR1 mutation with low nM IC50 values. |
