| Cat. No. |
Product Name |
Information |
| PC-21622 |
Fulvestrant
ER inhibitor
|
Fulvestrant (ICI 182780) is a steroidal antiestrogen, and potent, specific estrogen receptor (ER) antagonist with IC50 of 0.94 nM. |
| PC-21008 |
CIDD-0149897
ERβ agonist
|
CIDD-0149897 is a potent, selective, brain permeable estrogen receptor beta (ERβ) agonist, 40-fold selective over ERα. |
| PC-20982 |
SLU-PP-915
ERR agonist
|
SLU-PP-915 is a potent pan-ERR (Estrogen-related receptor) nuclear receptor agonist with EC50 of 414/435/378 nM for ERRα/ERRβ/ERRγ, respectively. |
| PC-20547 |
Palazestrant
ER antagonist
|
Palazestrant (OP-1250) is a potent, orally bioavailable complete estrogen receptor (ER) antagonist (IC50=6.4 nM) and selective ER degrader, blocks activity of both AF1 and AF2. |
| PC-20417 |
SLU-PP-1072
ERRα/γ inverse agonist
|
SLU-PP-1072 is a potent, selective, dual ERRα/γ inverse agonist, inhibits ERRα- and ERRγ-dependent transcription in cotransfection assays with IC50 of 4.8 and 0.9 uM. |
| PC-20416 |
SLU-PP-332
ERR agonist
|
SLU-PP-332 is a potent, selective pan ERRα/β/γ agonist with EC50 of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, in full-length ERR cell-based cotransfection/reporter assays. |
| PC-20415 |
GSK4716
ERRβ/γ agonist
|
GSK4716 (GSK 4716) is a selective agonist of estrogen-related receptors ERRβ and ERRγ with EC50 of 1.3 uM (ERRγ). |
| PC-20414 |
DY131
ERRβ/γ agonist
|
DY131 (GSK 9089) is a selective agonist of the ERRβ/γ receptor with EC50 of 130 nM, does not affect the ERRα, ERα and β (IC50>30 uM). |
| PC-49259 |
SMIP34
PELP1 inhibitor
|
SMIP34 (Small Molecule Inhibitor of PELP1 34) is a first-in-class, small molecule inhibitor of estrogen receptor (ER) coregulator PELP1, binds to (Kd=37.4 uM) and reduces PELP1 oncogenic functions. |
| PC-49172 |
H3B-6545 hydrochloride
ERα antagonist
|
H3B-6545 hydrochloride is a potent, covalent antagonist of both wild-type and mutant estrogen receptor alpha (ERα), shows antiproliferative activity for ERαWT and ERαY537S overexpressing MCF7 cells with or without H524 L ESR1 mutation with low nM IC50 values. |
| PC-49171 |
H3B-6545
ERα antagonist
|
H3B-6545 is a potent, covalent antagonist of both wild-type and mutant estrogen receptor alpha (ERα), shows antiproliferative activity for ERαWT and ERαY537S overexpressing MCF7 cells with or without H524 L ESR1 mutation with low nM IC50 values. |
| PC-49158 |
JND003
ERRα agonist
|
JND003 is a potent, selective and orally bioavailable ERRα agonist with EC50 of 86.0 nM for enhancing the interaction between ERRα and PGC1α peptide in AlphaScreen assays, exhibits an EC50 value of 2.7 uM in AAB-Luc cells stably expressing ERRα luciferase reporter. |
