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Cat. No. Product Name Information
PC-20547

Palazestrant

Estrogen receptor inhibitor

Palazestrant (OP-1250) is a potent, orally bioavailable complete estrogen receptor (ER) antagonist (IC50=6.4 nM) and selective ER degrader, blocks activity of both AF1 and AF2.
PC-20416

SLU-PP-332

ERR agonist

SLU-PP-332 is a potent, selective pan ERRα/β/γ agonist with EC50 of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, in full-length ERR cell-based cotransfection/reporter assays.
PC-49259

SMIP34

PELP1 inhibitor

SMIP34 (Small Molecule Inhibitor of PELP1 34) is a first-in-class, small molecule inhibitor of estrogen receptor (ER) coregulator PELP1, binds to (Kd=37.4 uM) and reduces PELP1 oncogenic functions.
PC-49171

H3B-6545

ERα antagonist

H3B-6545 is a potent, covalent antagonist of both wild-type and mutant estrogen receptor alpha (ERα), shows antiproliferative activity for ERαWT and ERαY537S overexpressing MCF7 cells with or without H524 L ESR1 mutation with low nM IC50 values.
PC-49158

JND003

ERRα agonist

JND003 is a potent, selective and orally bioavailable ERRα agonist with EC50 of 86.0 nM for enhancing the interaction between ERRα and PGC1α peptide in AlphaScreen assays, exhibits an EC50 value of 2.7 uM in AAB-Luc cells stably expressing ERRα luciferase reporter.
PC-73421

Imlunestrant

SERD and ER inhibitor

Imlunestrant (LY 3484356) is a potent, oral, selective estrogen receptor degrader (SERD) and pure estrogen receptor antagonist with Ki values of 0.64 nM and 2.8 nM against WT ERα and Y537S mutant ERα proteins, respectively.
PC-73108

SAR439859

SERD

SAR439859 (Amcenestrant) is a potent, orally available, selective estrogen receptor degrader (SERD) with IC50 of 0.2 nM (ERα degradation).
PC-73046

GNE-274

ER partial agonist

GNE-274 (GNE274) is a small molecule non-degrader, partial agonist of estrogen receptor (ER), failed to trigger increased ER turnover in tested cell line.
PC-72965

GSK5182

ERRγ inverse agonist

GSK5182 (GSK-5182) is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with IC50 of 79 nM.
PC-72964

DN200434

ERRγ inverse agonist

DN200434 (DN-200434) is a highly potent (functional IC50=6 nM, binding IC50=40 nM), selective, biocompatible and orally available ERRγ inverse agonist.
PC-72914

TTC-352

ER mimic agonist

TTC-352 (TTC352) is a synthetic selective estrogen mimic acts as estrogen receptor (ER) partial agonist for the treatment of endocrine-resistant breast cancer.
PC-72844

ErSO

UPR activator

ErSO is a small molecule activator of the unfolded protein response (UPR), activates the a-UPR, induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro.

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