| Cat. No. |
Product Name |
Information |
| PC-23654 |
EGX358
ERβ agonist
|
EGX358 (ISP358-2) is a potent, highly selective estrogen receptor-beta (ERβ) agonist with EC50 of 27 nM, 750-fold selectivity for ERβ over ERα. |
| PC-23616 |
Toremifene
SERM, Filovirus inhibitor
|
Toremifene (Z-Toremifene, NK 622 free base) is a selective estrogen receptor modulator (SERM), inhibits ebolavirus (EBOV) entry after internalization, shows potent antiviral activity in HepG2 cell lines with IC50 of 25.5 nM. |
| PC-23562 |
VPC-260724
ER-AF2 inhibitor
|
VPC-260724 is a specific small molecule inhibitor of estrogen receptor-activation function 2 (ER-AF2) with IC50 of 5.7 uM for inhibition of ER transcription in T47D-KBluc cells. |
| PC-23322 |
SR-16234
SERM
|
SR-16234 (TAS-108) is a selective estrogen receptor modulator (SERM), blocks both the N-terminal AF-1 and C-terminal AF-2 transactivation functions. |
| PC-22707 |
27-hydroxycholesterol
SERM
|
27-Hydroxycholesterol (27-OHC, 27HC) is a selective estrogen receptor (ER) modulator and an agonist of the liver X receptor (LXR), regulates both gene transcription and cell proliferation in cellular models of breast cancer. |
| PC-22504 |
T6I-29-1A
SERM
|
T6I-29-1A is the active enantiomer of T6I-29, which is a novel isoquinoline-based selective estrogen receptor modulator (SERM), interacts with Y537S ERα ligand binding domain (LBD), exhibits anti-proliferative activities. |
| PC-22503 |
T6I-29
SERM
|
T6I-29 is a novel isoquinoline-based selective estrogen receptor modulator (SERM), interacts with Y537S ERα ligand binding domain (LBD), exhibits anti-proliferative activities, downregulates target genes, and elicits anti-tumoral activities. |
| PC-21730 |
ERB-041
ERβ agonist
|
Prinaberel (ERB-041) is a potent, selective estrogen receptor beta (ERβ) agonist with IC50 of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. |
| PC-21622 |
Fulvestrant
ER inhibitor
|
Fulvestrant (ICI 182780) is a steroidal antiestrogen, and potent, specific estrogen receptor (ER) antagonist with IC50 of 0.94 nM. |
| PC-21173 |
Raloxifene
SERM
|
Raloxifene (Keoxifene, LY139481) is potent, selective estrogen receptor modulator (SERM). |
| PC-20995 |
X15695
ERα degrader
|
X15695 is a potent, selective and orally active estrogen receptor alpha (ERα) degrader, destabilizes ERα and stabilizes p53, inhibits ER+ breast cancer cell growth. |
| PC-20524 |
GNE-149
ER degrader
|
GNE-149 (GNE149) is a potent, full estrogen receptor alpha (ERα) antagonist and degrader with IC50 of 0.053 nM (MCF7, ERα degradation). |
