Catalog No.: PC-24543Not For Human Use, Lab Use Only.
Lasofoxifene (CP-336156, CP-336,156) is a potent, orally active, nonsteroidal selective estrogen receptor modulator (SERM), binds selectively and with high affinity to the human ERα with IC50 of 1.5 nM.
Lasofoxifene (CP-336156, CP-336,156) is a potent, orally active, nonsteroidal selective estrogen receptor modulator (SERM), binds selectively and with high affinity to the human ERα with IC50 of 1.5 nM. Lasofoxifene (CP-336156, CP-336,156) is potent and efficacious as estrogen at preventing bone loss and lowering total serum cholesterol in rats, shows no estrogen-like proliferative effects on breast and uterine tissue. Lasofoxifene (CP-336156, CP-336,156) induced apoptosis and p53 expression with a concomitant decrease in the number of tartrate-resistant acid phosphatase-positive multinuclear cells in rat bone marrow cell cultures in vitro. Lasofoxifene (CP-336156, CP-336,156) decreased total serum cholesterol and fat body mass and had no effect on lean body mass in female rats.
