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Cat. No. Product Name Information
PC-21622

Fulvestrant

ER inhibitor

Fulvestrant (ICI 182780) is a steroidal antiestrogen, and potent, specific estrogen receptor (ER) antagonist with IC50 of 0.94 nM.
PC-21173

Raloxifene

SERM

Raloxifene (Keoxifene, LY139481) is potent, selective estrogen receptor modulator (SERM).
PC-21008

CIDD-0149897

ERβ agonist

CIDD-0149897 is a potent, selective, brain permeable estrogen receptor beta (ERβ) agonist, 40-fold selective over ERα.
PC-20982

SLU-PP-915

ERR agonist

SLU-PP-915 is a potent pan-ERR (Estrogen-related receptor) nuclear receptor agonist with EC50 of 414/435/378 nM for ERRα/ERRβ/ERRγ, respectively.
PC-20547

Palazestrant

ER antagonist

Palazestrant (OP-1250) is a potent, orally bioavailable complete estrogen receptor (ER) antagonist (IC50=6.4 nM) and selective ER degrader, blocks activity of both AF1 and AF2.
PC-20417

SLU-PP-1072

ERRα/γ inverse agonist

SLU-PP-1072 is a potent, selective, dual ERRα/γ inverse agonist, inhibits ERRα- and ERRγ-dependent transcription in cotransfection assays with IC50 of 4.8 and 0.9 uM.
PC-20416

SLU-PP-332

ERR agonist

SLU-PP-332 is a potent, selective pan ERRα/β/γ agonist with EC50 of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, in full-length ERR cell-based cotransfection/reporter assays.
PC-20415

GSK4716

ERRβ/γ agonist

GSK4716 (GSK 4716) is a selective agonist of estrogen-related receptors ERRβ and ERRγ with EC50 of 1.3 uM (ERRγ).
PC-20414

DY131

ERRβ/γ agonist

DY131 (GSK 9089) is a selective agonist of the ERRβ/γ receptor with EC50 of 130 nM, does not affect the ERRα, ERα and β (IC50>30 uM).
PC-49259

SMIP34

PELP1 inhibitor

SMIP34 (Small Molecule Inhibitor of PELP1 34) is a first-in-class, small molecule inhibitor of estrogen receptor (ER) coregulator PELP1, binds to (Kd=37.4 uM) and reduces PELP1 oncogenic functions.
PC-49172

H3B-6545 hydrochloride

ERα antagonist

H3B-6545 hydrochloride is a potent, covalent antagonist of both wild-type and mutant estrogen receptor alpha (ERα), shows antiproliferative activity for ERαWT and ERαY537S overexpressing MCF7 cells with or without H524 L ESR1 mutation with low nM IC50 values.
PC-49171

H3B-6545

ERα antagonist

H3B-6545 is a potent, covalent antagonist of both wild-type and mutant estrogen receptor alpha (ERα), shows antiproliferative activity for ERαWT and ERαY537S overexpressing MCF7 cells with or without H524 L ESR1 mutation with low nM IC50 values.

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