Fulvestrant | ER inhibitor | Probechem Biochemicals

Chemical Structure : Fulvestrant

CAS No.: 129453-61-8

Fulvestrant (ICI 182780, ICI 164,384)

Catalog No.: PC-21622Not For Human Use, Lab Use Only.

Fulvestrant (ICI 182780) is a steroidal antiestrogen, and potent, specific estrogen receptor (ER) antagonist with IC50 of 0.94 nM.

Packing	Price	Stock
50 mg	$118	In stock
100 mg	$158	In stock
200 mg	$228	In stock
1 g	$398	In stock
5 g		Get quote

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Biological Activity

Fulvestrant (ICI 182780) is a steroidal antiestrogen, and potent, specific estrogen receptor (ER) antagonist with IC50 of 0.94 nM.
Fulvestrant (ICI 182780) effectively inhibits the growth of ER-positive MCF-7 cells with IC50 of 0.29 nM.
Fulvestrant (ICI 182780) is a more effective inhibitor of MCF-7 growth than 4'-hydroxytamoxifen.
Fulvestrant (ICI 182780) exhibits antitumor activity in xenografts of MCF-7 and Br10 human breast cancers in nude mice.

Physicochemical Properties

M.Wt	606.78
Formula	C32H47F5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

References

1. Yu X, et al. Mol Cancer. 2015 Dec 15;14:208.

2. Wakeling AE, et al. Cancer Res. 1991 Aug 1;51(15):3867-73.

3. Brünner N, et al. Cancer Res. 1993 Jul 15;53(14):3229-32.

Fulvestrant (ICI 182780, ICI 164,384)

Biological Activity

Physicochemical Properties

References

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