CIDD-0149897 is a potent, selective, brain permeable estrogen receptor beta (ERβ) agonist, 40-fold selective over ERα.
CIDD-0149897 markedly reduced GBM cell viability with an IC50 of ~7-15 µM, while having little to no effect on ERβ-KO cells and normal human astrocytes.
CIDD-0149897 enhanced expression of known ERβ target genes and promoted apoptosis in established and patient-derived GSC models.
CIDD-0149897 significantly decreased tumor growth in U251 xenograft model and extended the survival of orthotopic GBM tumor-bearing mice.
