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Chemical Structure : CIDD-0149897
CAS No.: 2862784-20-9
Catalog No.: PC-21008Not For Human Use, Lab Use Only.
CIDD-0149897 is a potent, selective, brain permeable estrogen receptor beta (ERβ) agonist, 40-fold selective over ERα.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CIDD-0149897 is a potent, selective, brain permeable estrogen receptor beta (ERβ) agonist, 40-fold selective over ERα.
CIDD-0149897 markedly reduced GBM cell viability with an IC50 of ~7-15 µM, while having little to no effect on ERβ-KO cells and normal human astrocytes.
CIDD-0149897 enhanced expression of known ERβ target genes and promoted apoptosis in established and patient-derived GSC models.
CIDD-0149897 significantly decreased tumor growth in U251 xenograft model and extended the survival of orthotopic GBM tumor-bearing mice.
| M.Wt | 271.25 | |
| Formula | C15H10FNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(2Z)-6-(3-fluoro-4-hydroxyphenyl)-2-hydroxyimino-3H-inden-1-one |
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1. Uday P Pratap, et al. Mol Cancer Ther. 2023 Jul 26;MCT-23-0031.
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