Catalog No.: PC-20416Not For Human Use, Lab Use Only.
SLU-PP-332 is a potent, selective pan ERRα/β/γ agonist with EC50 of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, in full-length ERR cell-based cotransfection/reporter assays.
SLU-PP-332 is a potent, selective pan ERRα/β/γ agonist with EC50 of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, in full-length ERR cell-based cotransfection/reporter assays.
SLU-PP-332 displays a degree of ERRα selectivity with 4.4-fold selectivity for ERRα over ERRγ and 2.3-fold ERRα over ERRβ.
SLU-PP-332 also displays activity at all ERRs in a Gal4-ERR LBD chimeric cotransfection assay, SLU-PP-332 is more potent at ERRα than ERRβ and ERRγ.
SLU-PP-332 is selective for the ERRs, does not alter the activity of either ERα or ERβ, or other nuclear receptors in cotransfection assays.
SLU-PP-332 (0.1-5 uM) increases the expression of an ERR target gene (pyruvate dehydrogenase kinase 4 (Pdk4)) and enhances mitochondrial respiration in C2C12 myocytes.
SLU-PP-332 (50 mg/kg, b.i.d, i.p.) increases oxidative fibers in skeletal muscle and improves exercise endurance in C57BL/6J mice.
SLU-PP-332 induces acute aerobic exercise genetic program in skeletal muscles, induces Ddit4 expression and enhances exercise endurance in an ERRα-dependent manner.
