| Cat. No. |
Product Name |
Information |
| PC-49306 |
MR120
|
MR120 (CCR6 antagonist 1b) is a potent, selective CCR6 antagonist, disrupts the CCL20-induced chemotaxis of CCR6+CD4+ T cells. |
| PC-49202 |
AMD3465
|
AMD3465 (AMD 3465) is a potent, selective monomacrocyclic CXCR4 antagonist with IC50 of 0.75 nM for inhibition of 12G5 mAb binding to CXCR4, dose-dependently inhibits CXCL12 binding in SupT1 cells with IC50 of 18 nM. |
| PC-49201 |
BPRCX714
|
BPRCX714 (BPRCX 714) is a highly selective and potent CXCR4 antagonist with binding IC50 of 34.2 nM, effectively inhibits CXCL12-induced movement of CCRF-CEM cells with EC50 of 13.7 nM. |
| PC-49200 |
BPRCX807
|
BPRCX807 (BPRCX-807) is a highly selective and potent CXCR4 antagonist with binding IC50 of 40.4 nM and EC50 of 48.1 nM for cell-mobility activity in the chemotaxis assays, inhibits CXCL12-mediated cell signaling pathway. |
| PC-49142 |
BMS-753426
|
BMS-753426 is a potent, selective and orally bioavailable antagonist of CCR2 with binding IC50 of 2.7 nM, 30-fold selectivity over CCR5. |
| PC-38499 |
Cenicriviroc
|
Cenicriviroc (TAK-652, TBR-652) is a potent, selective, orally active, dual CCR2/CCR5 antagonist with IC50 of 5.9/0.29 nM, inhibits both HIV-1 and HIV-2 and prevents viral cellular entry. |
| PC-38366 |
Lazucirnon
|
Lazucirnon (KST4290, ALK4290) is a small molecule, orally active inhibitor against CCR3, the natural receptor for chemokine eotaxin, decreases inflammatory cytokines in preclinical models. |
