| Cat. No. |
Product Name |
Information |
| PC-73268 |
NBI-74330
CXCR3 antagonist
|
NBI-74330 is a potent, selective CXC chemokine receptor 3 (CXCR3) antagonist, inhibits [(125)I]CXCL10 and [(125)I]CXCL11 specific binding with Ki of 1.5 and 2.3 nM, respectively. |
| PC-73267 |
AMD3451
CXCR5/CXCR4 antagonist
|
AMD3451 is a specific, dual CXCR5/CXCR4 antagonist with antiviral activity against a wide variety of HIV-1 and HIV-2 (IC50=1.2 to 26.5 uM) in vitro. |
| PC-73266 |
AstraZeneca CCR4 antagonist
CCR4 antagonist
|
AstraZeneca CCR4 antagonist is a potent, selective CCR4 antagonist, inhibits CCR4 ligand macrophage-derived chemokine (MDC/CCL22) in CCR4+CD4+ T cells. |
| PC-73265 |
RS-1748
CCR4 antagonist
|
RS-1748 is a highly potent, selective, orallu active CCR4 antagonist, inhibits [125I]CCL17 binding to human CCR4 with IC50 of 27.7 nM. |
| PC-73264 |
RS-1269
CCR4 antagonist
|
RS-1269 is a highly potent, selective CCR4 antagonist, inhibits [125I]CCL17 binding to human CCR4 with IC50 of 27.7 nM. |
| PC-73263 |
CCR4-IN-22
CCR4 antagonist
|
CCR4-IN-22 (Compound 22) is a potent, selective CCR4 antagonist with IC50 of 20 nM, efficiently inhibits CCR4-mediated Ca2+ mobilization and chemotaxis in vitro with IC50 of 3 and 7 nM, repectively. |
| PC-73262 |
GSK2239633A
CCR4 antagonist
|
GSK2239633A is a potent, allosteric CC-chemokine receptor 4 (CCR4) antagonist with pIC50 of 7.83 in 35S-GTPγS competition assay. |
| PC-73261 |
BMS-570520
CCR3 antagonist
|
BMS-570520 is a potent, selective CCR3 antagonist with IC50 of 1.9 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.068 nM. |
| PC-73260 |
DPC168
CCR3 antagonist
|
DPC168 (DPC-168) is a highly potent, selective CC chemokine receptor-3 (CCR3) antagonist with IC50 of 2.0 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.034 nM. |
| PC-73259 |
IS811
CCR3 antagonist
|
IS811 is a potent, selective CCR3 antagonist with IC50 of 2.0 nM, potently inhibits chemotaxis with EC50 of 19 nM. |
| PC-73250 |
CCR7 inhibitor Cmp1205
CCR7 inhibitor
|
CCR7 inhibitor Cmp1205 is an allosteric ligand and antagonist for human CC chemokine receptor 7 (CCR7) with Kd of 3 nM, suppresses arrestin binding in response to activation by CCL19 with IC50 of 7.3 uM. |
| PC-73249 |
Vercirnon
CCR9 inhibitor
|
Vercirnon (GSK1605786, CCX282-B) is a potent, selective, orally bioavailable antagonist of CCR9, inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 of 5.4 and 3.4 nM, respectively. |
