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Cat. No. Product Name Information
PC-61576

INCB10820

Dual CCR2/5 antagonist

INCB10820 (PF-4178903) is a potent, selective, orally bioavailable dual CCR2 and CCR5 antagonist with binding IC50 of 3.0 nM and 5.3 nM, respectively.
PC-61558

PF-04634817

CCR2/5 antagonist

PF-04634817 is a potent, orally bioavailble CCR2 and CCR5 chemokine receptor antagonist for the treatment of diabetic nephropathies and diabetic macular oedema. .
PC-61557

PF-04136309

CCR2 antagonist

PF-4136309 (INCB8761) is a potent, selective, competitive, reversible full CCR2 antagonist with IC50 of 2-5 nM.
PC-61474

Ladarixin

CXCR1/CXCR2 inhibitor

Ladarixin (DF 2156) is an allosteric, noncompetitive dual CXCR1/2 inhibitor that inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 in vitro with IC50 of 0.7 nM.
PC-61471

AZD-8309

AZD-8309 (AZD8309) is a potent and orally bioavailable CXCR2 antagonist that has been proposed to regulate the transmigration of neutrophils.
PC-61467

ST 016907

CCR4 antagonist

ST 016907 is a potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.
PC-61466

AF-399 42016530

CCR4 antagonist

AF-399/42016530 is a potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.
PC-61317

LY-2510924

CXCR4 inhibitor

LY-2510924 (LY2510924) is a potent and selective, cyclic peptide CXCR4 antagonist with IC50 of 0.079 nM, without apparent agonist activity.
PC-61294

KRH-3955

KRH-3955 is a potent, selective, orally bioavailable inhibitor of CXCR4 that efficiently inhibits SDF-1α binding to CXCR4 with IC50 of 0.61 nM.
PC-61293

Balixafortide

CXCR4 antagonist

Balixafortide (POL6326) is a potent, selective, peptidic CXCR4 antagonist that interferes with the tumor-protective microenvironment and sensitizes tumor cells to chemotherapy.
PC-61292

KRH-1636

CXCR4 inhibitor

KRH-1636 (KRH1636) is a potent, selective inhibitor of CXCR4 with IC50 of 13 nM, has no effect on CXCR1, CCR3, CCR4, or CCR5.
PC-61173

NVP-BDZ 824

CXCR3 inhibitor

NVP-BDZ 824 is a potent, highly selective antagonist of chemokine receptor CXCR3 with binding IC50 of 146 nM, Ca2+-mobilization IC50 of 28 nM.

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