Catalog No.: PC-35088Not For Human Use, Lab Use Only.
GSK812397 is a potent, selective, noncompetitive, orally available antagonist of CXCR4 receptor, inhibits entry of X4-tropic strains of HIV-1 with IC50 of 4.60 nM and 1.50 nM in PBMCs and HOS assays, respectively.
GSK812397 is a potent, selective, noncompetitive, orally available antagonist of CXCR4 receptor, inhibits entry of X4-tropic strains of HIV-1 with IC50 of 4.60 nM and 1.50 nM in PBMCs and HOS assays, respectively.
GSK812397 does not block CCR5-mediated viral entry in the R5 viral HOS assay (IC50>25 uM).
GSK812397 produces a concentration-dependent decrease in both an SDF-1-mediated chemotaxis and intracellular calcium release (IC50=0.34 nM and 2.41 nM, respectively) in cell-based functional assays.
GSK812397 demonstrates antiviral activity against a broad range of X4-utilizing strains of HIV-1.
