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CCX-354

Chemical Structure : CCX-354

CAS No.: 1010073-75-2

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CCX-354 (GSK-2941266;CCX354;CCX354-C)

Catalog No.: PC-35832Not For Human Use, Lab Use Only.

CCX-354 (GSK-2941266, CCX354-C, CCX354) is a potent, selective, orally-available CCR1 antagonist for the treatment of inflammatory diseases such as rheumatoid arthritis (RA).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CCX-354 (GSK-2941266, CCX354-C, CCX354) is a potent, selective, orally-available CCR1 antagonist for the treatment of inflammatory diseases such as rheumatoid arthritis (RA).

Physicochemical Properties

M.Wt 451.915
Formula C22H22ClN7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-(4-chloro-3-methoxyphenyl)piperazin-1-yl)ethan-1-one

References

1. Tak PP, et al. Ann Rheum Dis. 2013 Mar;72(3):337-44.

2. Harcken C, et al. Bioorg Med Chem Lett. 2018 Nov 9. pii: S0960-894X(18)30880-1.

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