Chemical Structure : GW 766994
CAS No.: 408303-43-5
Catalog No.: PC-35226Not For Human Use, Lab Use Only.
GW 766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays.
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GW 766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays.
GW-766994 reverses CCL11-induced activation of CDK5 at 10 uM in rat neurons expressed CCR3.
GW-766994 blocks CCL11-induced the production of Aβ and dendritic spine loss in the hippocampal neuronal cultures.
M.Wt | 451.348 | |
Formula | C21H24Cl2N4O3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(S)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzamide |
1. Neighbour H, et al. Clin Exp Allergy. 2014 Apr;44(4):508-16.
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