Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-GPCR-Chemokine Receptor (CCR and CXCR)-GW 766994
GW 766994

Chemical Structure : GW 766994

CAS No.: 408303-43-5

GW 766994 (GW766994)

Catalog No.: PC-35226Not For Human Use, Lab Use Only.

GW 766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays.

Packing Price Stock Quantity
5 mg $298 In stock
10 mg $458 In stock
25 mg $758 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GW 766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays.
GW-766994 reverses CCL11-induced activation of CDK5 at 10 uM in rat neurons expressed CCR3.
GW-766994 blocks CCL11-induced the production of Aβ and dendritic spine loss in the hippocampal neuronal cultures.

Physicochemical Properties

M.Wt 451.348
Formula C21H24Cl2N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzamide

References

1. Neighbour H, et al. Clin Exp Allergy. 2014 Apr;44(4):508-16.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: