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CXCR6 inhibitor 81

Chemical Structure : CXCR6 inhibitor 81

CAS No.: 2579689-85-1

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CXCR6 inhibitor 81

Catalog No.: PC-38129Not For Human Use, Lab Use Only.

CXCR6 inhibitor 81 is a potent (EC50=40 nM) and selective orally bioavailable small molecule antagonist of human CXCR6 receptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CXCR6 inhibitor 81 is a potent (EC50=40 nM) and selective orally bioavailable small molecule antagonist of human CXCR6 receptor.
    Compound 81 displays >10-fold improvement in potency in both the β-arrestin and cAMP assays (IC50 =40 and 540 nM, respectively) compared to ML339.
    CXCR6 inhibitor 81 inhibits migration of SK-HEP-1 hepatoma cells in a dose dependent manner.
    Compound 81 has promising oral DMPK data, significantly decreases tumor growth in a 30-day mouse xenograft model of HCC.

    Physicochemical Properties

    M.Wt 549.609
    Formula C27H30F3N3O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 1 Month
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3,4,5-trimethoxy-N-((1R,3s,5S)-9-((4-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-9-azabicyclo[3.3.1]nonan3-yl)benzamide

    References

    1. Satyamaheshwar Peddibhotla, et al. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126899.

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