| Cat. No. |
Product Name |
Information |
| PC-20732 |
YM-344484
Dual CCR3/H1 antagonist
|
YM-344484 (YM344484) is a potent, selective dual antagonist of chemokine CCR3 receptor and histamine H1 receptor, potently inhibits both the CCL11-induced Ca2+ influx in human CCR3-expressing cells (Kb=1.8 nM) and histamine-induced Ca2+ influx in histamine H1 receptor-expressing PC3 cells (Kb=47 nM). |
| PC-20731 |
GW782415W
CCR3 antagonist
|
GW782415W (GW782415) is a potent, specific CCR3 antagonist, inhibits chemotaxis of human and murine eosinophils pKi of 8.08 and 7.85, respectively. |
| PC-20730 |
BMS-639623
CCR3 antagonist
|
BMS-639623 is a potent, selective and orally bioavailable CCR3 antagonist with binding IC50 of 0.3 nM and chemotaxis IC50 of 0.04 nM. |
| PC-20729 |
AZD3778
Dual CCR3/H1 antagonist
|
AZD3778 (AZD-3778) is a dual CCR3 and H1-receptor antagonistwith Ki of 54 nM for guinea-pig H1-receptor, inhibits binding of CR3 radioligand 125I-eotaxin to human CCR3-receptor expressed on CHO-cells with IC50 of 8 nM. |
| PC-20728 |
Ki19003
CCR3 antagonist
|
Ki19003 (Ki 19003) is a potent, specific CCR3 antagonist, inhibits the CCL11-induced migration of CCR3-expressing L1.2 cells with IC50 of 20 nM. |
| PC-20727 |
AZ12436092
CCR3 antagonist
|
AZ12436092 (AZ 12436092) is a potent, selective CCR3 antagonist with binding pKi value of 9.2. |
| PC-20726 |
YM-344031
CCR3 antagonist
|
YM-344031 is a potent, selective, brain-penetrable CCR3 antagonist with binding IC50 of 3.0 nM, inhibits ligand-induced Ca(2+) flux with IC50 of 5.4 nM. |
| PC-20725 |
YM-355179
CCR3 antagonist
|
YM-355179 is a potent selective, and orally available antagonist of CC chemokine receptor 3 (CCR3) with binding IC50 of 7.6 nM (CCL5). |
| PC-20724 |
SB-297006
CCR3 antagonist
|
SB-297006 is a potent, selective non-peptide CC chemokine receptor-3 (CCR3) antagonist, inhibits 125I-eotaxin binding to human eosinophils with IC50 of 60 nM. |
| PC-20723 |
SB-328437
CCR3 antagonist
|
SB-328437 is a potent, selective non-peptide CC chemokine receptor-3 (CCR3) antagonist, inhibits 125I-eotaxin binding to human eosinophils with IC50 of 4.5 nM. |
| PC-20542 |
J-113863
CCR1 inhibitor
|
J-113863 is a potent, selective, non-peptide antagonist of CCR1 with IC50 of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively. |
| PC-20541 |
UCB35625
CCR1 inhibitor
|
UCB35625 is a potent, selective inhibitor of CCR1 and CCR3, inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants with IC50 of 9.57 and 93.8 nM respectively. |
