| Cat. No. |
Product Name |
Information |
| PC-21897 |
Maraviroc
CCR5 antagonist
|
Maraviroc (UK-427857) is a potent, selective and orally bioavailable CCR5 inhibitor with IC50 of 3.3 nM, 7.2 nM and 5.2 nM for MIP-1α, MIP-1β and RANTES binding to cell membrane preparations of CCR5-expressing HEK-293, shows broad-spectrum activity against HIV-1. |
| PC-21816 |
VUF11222
CXCR3 agonist
|
VUF11222 is a potent, selective and nonpeptidomimetic CXCR3 agonist with binding pKi of 7.2, and pEC50 of 6.1 in [35S]GTPγS functional assays. |
| PC-21785 |
VUF15485
ACKR3 agonist
|
VUF15485 is a small-molecule agonist of the atypical chemokine receptor ACKR3 with binding pIC50 of 8.3, and pEC50 of 7.6 in BRET-based β-arrestin2 recruitment assay. |
| PC-21292 |
GPC-100 hydrobromide
CXCR4 antagonist
|
GPC-100 (TG-0054, Burixafor) is a novel small molecule antagonist of CXCR4, shows competitive inhibition of CXCL12 binding to CXCR4 with Ki of 1.6 nM. |
| PC-21104 |
DAPTA
CCR5 antagonist
|
DAPTA (D-ala-peptide T-amide, Adaptavir) is an HIV gp120-derived CCR5 entry inhibitor, inhibits CCR5-mediated monocyte migration and attenuates neuroinflammation. |
| PC-21102 |
RAP-103
CCR2 antagonist
|
RAP-103 is an orally active, stabilized pentapeptide analog of DAPTA (D-ala-peptide T-amide), and multi-chemokine receptor antagonist. |
| PC-21101 |
UCUF-965
CXCR4 modulator
|
UCUF-965 (UCUF965) is a potent partial agonist and positive allosteric modulator of CXCR4 with EC50 of 0.02 uM, Emax=44% for CXCR4/CXCL12 signaling for β-arrestin-2 recruitment. |
| PC-20732 |
YM-344484
Dual CCR3/H1 antagonist
|
YM-344484 (YM344484) is a potent, selective dual antagonist of chemokine CCR3 receptor and histamine H1 receptor, potently inhibits both the CCL11-induced Ca2+ influx in human CCR3-expressing cells (Kb=1.8 nM) and histamine-induced Ca2+ influx in histamine H1 receptor-expressing PC3 cells (Kb=47 nM). |
| PC-20731 |
GW782415W
CCR3 antagonist
|
GW782415W (GW782415) is a potent, specific CCR3 antagonist, inhibits chemotaxis of human and murine eosinophils pKi of 8.08 and 7.85, respectively. |
| PC-20730 |
BMS-639623
CCR3 antagonist
|
BMS-639623 is a potent, selective and orally bioavailable CCR3 antagonist with binding IC50 of 0.3 nM and chemotaxis IC50 of 0.04 nM. |
| PC-20729 |
AZD3778
Dual CCR3/H1 antagonist
|
AZD3778 (AZD-3778) is a dual CCR3 and H1-receptor antagonistwith Ki of 54 nM for guinea-pig H1-receptor, inhibits binding of CR3 radioligand 125I-eotaxin to human CCR3-receptor expressed on CHO-cells with IC50 of 8 nM. |
| PC-20728 |
Ki19003
CCR3 antagonist
|
Ki19003 (Ki 19003) is a potent, specific CCR3 antagonist, inhibits the CCL11-induced migration of CCR3-expressing L1.2 cells with IC50 of 20 nM. |
