| Cat. No. |
Product Name |
Information |
| PC-43512 |
TAK-779
CCR5 antagonist
|
TAK-779 (TAK779) is a potent, specific, nonpeptide CCR5 antagonist with Kd of 0.45 nM, antagonizes CCR2b to a lesser extent (27 nM) but does not affect CCR1, CCR3, or CCR4. |
| PC-63440 |
R243
CCR8 antagonist
|
R243 is a potent, small molecule CCR8 antagonist that inhibits CCR8 signaling and chemotaxis, inhibits CCL1-induced Ca2+ flux and CCL1-driven peritoneal macrophages aggregation at 0.2 uM. |
| PC-42890 |
BX471 hydrochloride
CCR1 antagonist
|
BX471 is a potent, selective, orally available CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1. |
| PC-42889 |
BX471
CCR1 inhibitor
|
BX471 (BX-471) is a potent, selective, non-peptide CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1. |
| PC-62992 |
Aplaviroc hydrochloride
CCR5 inhibitor
|
Aplaviroc hydrochloride (GSK-873140;GW 873140;AK-602;ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6. |
| PC-62990 |
Elubrixin tosylate
CXCR2 antagonist
|
Elubrixin tosylate (SB-656933, GSK656933) is a potent, selective, competitive and reversible CXCR2 antagonist. |
| PC-62989 |
Elubrixin
CXCR2 antagonist
|
Elubrixin (SB-656933, GSK656933) is a potent, selective, competitive and reversible CXCR2 antagonist. |
| PC-62775 |
CXCR2 inhibitor 68
CXCR2 antagonist
|
CXCR2-IN-68 is a potent, selective, brain penetrant, and orally bioavailable CXCR2 antagonist with pIC50 of 9.0, displays 730-fold selectivity over CXCR1 and >1,900-fold selectivity over all other chemokine receptors. |
| PC-62762 |
AZD-4818
CCR1 inhibitor
|
AZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner. |
| PC-62752 |
C-021
CCR4 antagonist
|
C-021 is a potent and orally bioavailable CCR4 antagonist with IC50 of 0.14 uM and 0.039 uM for inhibition of chemotaxis in human and mouse, respectively.. |
| PC-61983 |
C-021 dihydrochloride
CCR4 antagonist
|
C-021 dihydrochloride is a potent and orally bioavailable CCR4 antagonist with IC50 of 0.14 uM and 0.039 uM for inhibition of chemotaxis in human and mouse, respectively.. |
| PC-61981 |
Tivumecirnon
CCR4 antagonist
|
Tivumecirnon (FLX475) is a potent, selective and orally bioavailable CCR4 antagonist, selectively and potently inhibit the migration of Treg to the TME (hTreg CTX, IC50=27 nM), blocks the migration of regulatory T cells (Treg) specifically into tumors. |
