Elubrixin (SB-656933, GSK656933)

Chemical Structure : Elubrixin

CAS No.: 688763-64-6

Catalog No.: PC-62989Not For Human Use, Lab Use Only.

Elubrixin (SB-656933, GSK656933) is a potent, selective, competitive and reversible CXCR2 antagonist.

Packing	Price	Stock
5 mg	$188	In stock
10 mg	$298	In stock
25 mg	$498	In stock
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Biological Activity

Elubrixin (SB-656933, GSK656933) is a potent, selective, competitive and reversible CXCR2 antagonist.
Elubrixin inhibits CXCL1-induced CD11b up-regulation on PMNs with IC50 of 26.07 nM in in vitro whole blood assay.
Elubrixin is active in in vivo rodent inhalation challenge models of airway inflammation that used endotoxin and ozone to induce airway neutrophilia.

Physicochemical Properties

M.Wt	463.305
Formula	C17H17Cl2FN4O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea

References

1. Lazaar AL, et al. Br J Clin Pharmacol. 2011 Aug;72(2):282-93.

2. Nicholson GC, et al. Pulm Pharmacol Ther. 2007;20(1):52-9.

3. Kaur M, et al. J Pharmacol Exp Ther. 2013 Oct;347(1):173-80.

4. Busch-Petersen J, et al. Curr Top Med Chem. 2006;6(13):1345-52.