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Aplaviroc hydrochloride

Chemical Structure : Aplaviroc hydrochloride

CAS No.: 461023-63-2

Aplaviroc hydrochloride (AK-602, GW 873140, ONO-4128, GSK-873140)

Catalog No.: PC-62992Not For Human Use, Lab Use Only.

Aplaviroc hydrochloride (GSK-873140;GW 873140;AK-602;ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Aplaviroc hydrochloride (GSK-873140;GW 873140;AK-602;ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6.
    Aplaviroc blocks the calcium response effects of CCR5 activation by CCL5, and potently blocks in vitro the infection of R5-tropic HIV-1 (R5-HIV-1) at subnanomolar IC50.

    Physicochemical Properties

    M.Wt 614.18
    Formula C33H44ClN3O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undecan-9-yl]methyl]phenoxy]benzoic acid hydrochloride

    References

    1. Watson C, et al. Mol Pharmacol. 2005 Apr;67(4):1268-82.

    2. Lalezari J, et al. AIDS. 2005 Sep 23;19(14):1443-8.

    3. Adkison KK, et al. Antimicrob Agents Chemother. 2005 Jul;49(7):2802-6.

    4. Nakata H, et al. Antimicrob Agents Chemother. 2008 Jun;52(6):2111-9.

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