Cat. No. |
Product Name |
Information |
PC-38487 |
VUF11418
CXCR3 agonist
|
VUF11418 is a selective, nonpeptidomimetic agonist of CXCR3 with binding pKi vaule of 7.2, pEC50 value of 6.0 in [35S]GTPγS functional assays. |
PC-73267 |
AMD3451
CXCR5/CXCR4 antagonist
|
AMD3451 is a specific, dual CXCR5/CXCR4 antagonist with antiviral activity against a wide variety of HIV-1 and HIV-2 (IC50=1.2 to 26.5 uM) in vitro. |
PC-73266 |
AstraZeneca CCR4 antagonist
CCR4 antagonist
|
AstraZeneca CCR4 antagonist is a potent, selective CCR4 antagonist, inhibits CCR4 ligand macrophage-derived chemokine (MDC/CCL22) in CCR4+CD4+ T cells. |
PC-73265 |
RS-1748
CCR4 antagonist
|
RS-1748 is a highly potent, selective, orallu active CCR4 antagonist, inhibits [125I]CCL17 binding to human CCR4 with IC50 of 27.7 nM. |
PC-73264 |
RS-1269
CCR4 antagonist
|
RS-1269 is a highly potent, selective CCR4 antagonist, inhibits [125I]CCL17 binding to human CCR4 with IC50 of 27.7 nM. |
PC-73263 |
CCR4-IN-22
CCR4 antagonist
|
CCR4-IN-22 (Compound 22) is a potent, selective CCR4 antagonist with IC50 of 20 nM, efficiently inhibits CCR4-mediated Ca2+ mobilization and chemotaxis in vitro with IC50 of 3 and 7 nM, repectively. |
PC-73262 |
GSK2239633A
CCR4 antagonist
|
GSK2239633A is a potent, allosteric CC-chemokine receptor 4 (CCR4) antagonist with pIC50 of 7.83 in 35S-GTPγS competition assay. |
PC-73171 |
USL311
CXCR4 inhibitor
|
USL311 is a potent, selective, orally bioavailable CXCR4 antagonist, with potential antineoplastic activity. |
PC-73125 |
SX-682
CXCR 1/2 inhibitor
|
SX-682 (SX682) is a potent, allosteric, orally bioavailable inhibitor of CXCR1 and CXCR2. |
PC-72032 |
HF50731
CXCR4 antagonist
|
HF50731 (HF-50731) is a novel potent, selective CXCR4 antagonist with Ki of 19.8 nM in the CXCR4 competitive binding assay. |
PC-35230 |
GW-766994 R-form
|
GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays. |
PC-42890 |
BX471 hydrochloride
|
BX471 is a potent, selective, orally available CCR1 antagonist with Ki of 1 nM for hCCR1, displays 100 times less affinity for rat CCR1. |