| Cat. No. |
Product Name |
Information |
| PC-21255 |
ZK756326
CCR8 agonist
|
ZK 756326 is a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8, inhibits the binding of the CCR8 ligand I-309 (CCL1) with IC50 of 1.8 uM. |
| PC-21104 |
DAPTA
CCR5 antagonist
|
DAPTA (D-ala-peptide T-amide, Adaptavir) is an HIV gp120-derived CCR5 entry inhibitor, inhibits CCR5-mediated monocyte migration and attenuates neuroinflammation. |
| PC-21102 |
RAP-103
CCR2 antagonist
|
RAP-103 is an orally active, stabilized pentapeptide analog of DAPTA (D-ala-peptide T-amide), and multi-chemokine receptor antagonist. |
| PC-21101 |
UCUF-965
CXCR4 modulator
|
UCUF-965 (UCUF965) is a potent partial agonist and positive allosteric modulator of CXCR4 with EC50 of 0.02 uM, Emax=44% for CXCR4/CXCL12 signaling for β-arrestin-2 recruitment. |
| PC-21011 |
KAND567
CX3CR1 inhibitor
|
KAND567 (AZD8797) is a potent, selective and orally available C-X3-C motif chemokine receptor 1 (CX3CR1, fractalkine receptor) antagonist with binding Ki of 3.9 nM (human CX3CR1), 720-fold selectivity over CXCR2. |
| PC-20971 |
CCR7 inhibitor 30c
CCR7 inhibitor
|
CCR7 inhibitor 30c is a potent, selective CC chemokine receptor 7 (CCR7) antagonist with IC50 of 0.43 uM, 25-fold selectivity over CXCR2. |
| PC-20802 |
SCH-479833
CXCR1/2 inhibitor
|
SCH-479833 is a potent, specific and orally active CXCR1 and CXCR2 antagonist with Ki of 0.17 and 7 nM, respectively. |
| PC-20761 |
PF-07054894
CCR6 inhibitor
|
PF-07054894 is a potent, functionally selective CCR6 antagonist, blocks in vitro CCL20- dependent human T cell chemotaxis with IC50 of 5.7 nM. |
| PC-20733 |
AMG487
CXCR3 antagonist
|
AMG487 (AMG 487, VUF10085) is a potent and selective orally bioavailable chemokine (C-X-C motif) receptor 3 (CXCR3) antagonist with IC50 of 8 nM for inhibiting 125I-IP-10 binding. |
| PC-20732 |
YM-344484
Dual CCR3/H1 antagonist
|
YM-344484 (YM344484) is a potent, selective dual antagonist of chemokine CCR3 receptor and histamine H1 receptor, potently inhibits both the CCL11-induced Ca2+ influx in human CCR3-expressing cells (Kb=1.8 nM) and histamine-induced Ca2+ influx in histamine H1 receptor-expressing PC3 cells (Kb=47 nM). |
| PC-20731 |
GW782415W
CCR3 antagonist
|
GW782415W (GW782415) is a potent, specific CCR3 antagonist, inhibits chemotaxis of human and murine eosinophils pKi of 8.08 and 7.85, respectively. |
| PC-20730 |
BMS-639623
CCR3 antagonist
|
BMS-639623 is a potent, selective and orally bioavailable CCR3 antagonist with binding IC50 of 0.3 nM and chemotaxis IC50 of 0.04 nM. |
