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Chemical Structure : ATI-2341
CAS No.: 1337878-62-2
Catalog No.: PC-60592Not For Human Use, Lab Use Only.
ATI-2341 is a potent, allosteric CXCR4 agonist with EC50 of 194 nM.
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|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $558 | In stock | |
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| 100 mg | Get quote |
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ATI-2341 is a potent, allosteric CXCR4 agonist with EC50 of 194 nM.
ATI-2341 induces CXCR4-dependent calcium flux in U87 glioblastoma cells (IC50=140 nM), receptor internalization, and chemotaxis in cell-based assays.
ATI-2341 also displays potent efficacy in the mobilization of PMNs and HSPCs in mice and nonhuman primates.
| M.Wt | 2256.82 | |
| Formula | C104H178N26O25S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
MGYQKKLRSMTDKYRL (Modifications: Met-1 = N-terminal Palmitoyl) |
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1. Tchernychev B, et al. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22255-9.
2. Janz JM, et al. J Am Chem Soc. 2011 Oct 12;133(40):15878-81.
3. Quoyer J, et al. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5088-97.
4. Luo J, et al. Mol Pharmacol. 2017 Jun;91(6):554-566.
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