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ATI-2341

Chemical Structure : ATI-2341

CAS No.: 1337878-62-2

ATI-2341 (ATI 2341;ATI2341)

Catalog No.: PC-60592Not For Human Use, Lab Use Only.

ATI-2341 is a potent, allosteric CXCR4 agonist with EC50 of 194 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ATI-2341 is a potent, allosteric CXCR4 agonist with EC50 of 194 nM.
ATI-2341 induces CXCR4-dependent calcium flux in U87 glioblastoma cells (IC50=140 nM), receptor internalization, and chemotaxis in cell-based assays.
ATI-2341 also displays potent efficacy in the mobilization of PMNs and HSPCs in mice and nonhuman primates.

Physicochemical Properties

M.Wt 2256.82
Formula C104H178N26O25S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

MGYQKKLRSMTDKYRL (Modifications: Met-1 = N-terminal Palmitoyl)

References

1. Tchernychev B, et al. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22255-9.

2. Janz JM, et al. J Am Chem Soc. 2011 Oct 12;133(40):15878-81.

3. Quoyer J, et al. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5088-97.

4. Luo J, et al. Mol Pharmacol. 2017 Jun;91(6):554-566.

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