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CX4338

Chemical Structure : CX4338

CAS No.: 41609-06-7

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CX4338 (CX-4338)

Catalog No.: PC-60623Not For Human Use, Lab Use Only.

CX4338 (CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CX4338 (CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM.
    CX4338 shows little to no inhibition of CXCR4-mediated β-arrestin-2 recruitment at 100 uM.
    CX4338 inhibits receptor internalization, while enhancing CXCR2-mediated MAPK activation.
    CX4338 inhibits CXCL8-induced chemotaxis in CXCR2-overexpressing cells and human neutrophils.
    CX4338 significantly reduces neutrophils in bronchoalveolar lavage induced by LPS in mice.

    Physicochemical Properties

    M.Wt 364.507
    Formula C22H24N2OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(benzylamino)-4,4-dimethyl-6-oxo-N-phenylcyclohex-1-enecarbothioamide

    References

    1. Ha H, et al. Br J Pharmacol. 2014 Mar;171(6):1551-65.

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