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Chemical Structure : CX 4338
Catalog No.: PC-60623Not For Human Use, Lab Use Only.
CX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM.
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CX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM; shows little to no inhibition of CXCR4-mediated β-arrestin-2 recruitment at 100 uM; inhibits receptor internalization, while enhancing CXCR2-mediated MAPK activation; inhibits CXCL8-induced chemotaxis in CXCR2-overexpressing cells and human neutrophils; significantly reduces neutrophils in bronchoalveolar lavage induced by LPS in mice.
| M.Wt | 364.507 | |
| Formula | C22H24N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ha H, et al. Br J Pharmacol. 2014 Mar;171(6):1551-65.
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