SX-576 |CAS:1240494-14-7 Probechem Biochemicals

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Chemical Structure : SX-576

SX-576 (SX 576;SX576)

Catalog No.: PC-60619Not For Human Use, Lab Use Only.

SX-576 is a potent, equipotent CXCR1 and CXCR2 antagonist with IC50 of 31 nM and 21 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SX-576 is a potent, equipotent CXCR1 and CXCR2 antagonist with IC50 of 31 nM and 21 nM, respectively.
SX-576 exhibits potent inhibition of neutrophil influx in rat model of pulmonary inflammation.

Physicochemical Properties

M.Wt	466.214
Formula	C20H15BF4N2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(((5-((4-fluorophenyl)carbamoyl)pyridin-2-yl)thio)methyl)-4-(trifluoromethoxy)phenyl)boronic acid

References

1. Maeda DY, et al. Bioorg Med Chem Lett. 2015 Jun 1;25(11):2280-4.

2. Schuler AD, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3793-7.

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SX-576 (SX 576;SX576)

Biological Activity

Physicochemical Properties

References

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