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Chemical Structure : PRX-177561
Catalog No.: PC-60339Not For Human Use, Lab Use Only.
PRX-177561 is a novel potent, selective, brain-penetrating, orally active CXCR4 antagonist with Ki of 3 nM.
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PRX-177561 is a novel potent, selective, brain-penetrating, orally active CXCR4 antagonist with Ki of 3 nM.
PRX-177561 inhibits tumor growth alone, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma.
PRX-177561 reduces the expression of Nestin in vivo, reduces tumor cell proliferation and accelerates cancer stem cell differentiation in glioblastoma preclinical models.
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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