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Chemical Structure : JNJ-27141491
Catalog No.: PC-60325Not For Human Use, Lab Use Only.
JNJ-27141491 is a potent, selective, noncompetitive, orally active CCR2 antagonist with IC50 of 172 nM.
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JNJ-27141491 is a potent, selective, noncompetitive, orally active CCR2 antagonist with IC50 of 172 nM.
JNJ-27141491 strongly suppresses MCP-1, -3, and -4-induced Ca(2+) mobilization; and leukocyte chemotaxis with IC50 of 7-97 nM, with no effect on other chemokine receptors.
JNJ-27141491 dose-dependently inhibits monocyte and neutrophil recruitment in mice.
| M.Wt | 379.38 | |
| Formula | C17H15F2N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zweemer AJ, et al. Mol Pharmacol. 2013 Oct;84(4):551-61.
2. Buntinx M, et al. J Pharmacol Exp Ther. 2008 Oct;327(1):1-9.
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