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JNJ-27141491

Chemical Structure : JNJ-27141491

CAS No.: 871313-59-6

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JNJ-27141491 (JNJ 27141491;JNJ27141491)

Catalog No.: PC-60325Not For Human Use, Lab Use Only.

JNJ-27141491 is a potent, selective, noncompetitive, orally active CCR2 antagonist with IC50 of 172 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JNJ-27141491 is a potent, selective, noncompetitive, orally active CCR2 antagonist with IC50 of 172 nM.
    JNJ-27141491 strongly suppresses MCP-1, -3, and -4-induced Ca(2+) mobilization; and leukocyte chemotaxis with IC50 of 7-97 nM, with no effect on other chemokine receptors.
    JNJ-27141491 dose-dependently inhibits monocyte and neutrophil recruitment in mice.

    Physicochemical Properties

    M.Wt 379.38
    Formula C17H15F2N3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-[(1S)-1-(3,4-Difluorophenyl)propyl]-2,3-dihydro-5-(5-isoxazolyl)-2-thioxo-1H-imidazole-4-carboxylic acid methyl ester

    References

    1. Zweemer AJ, et al. Mol Pharmacol. 2013 Oct;84(4):551-61.

    2. Buntinx M, et al. J Pharmacol Exp Ther. 2008 Oct;327(1):1-9.

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