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Chemical Structure : AZ 10397767
Catalog No.: PC-60617Not For Human Use, Lab Use Only.
AZ10397767 is a potent, selective CXCR2 inhibitor that inhibits CXCL8 binding to CXCR2 with pIC50 of 9.0.
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AZ10397767 is a potent, selective CXCR2 inhibitor that inhibits CXCL8 binding to CXCR2 with pIC50 of 9.0; weakly inhibits CXCL8 binding to CXCR1 with pIC50<7, and no affinity for CCR2 and CCR5; significantly attenuates IL-8-induced c-FLIP mRNA up-regulation whereas inhibition of AR- and/or NF-kappaB-mediated transcription attenuated IL-8-induced c-FLIP expression in LNCaP and PC3 cells, respectively; attenuates oxaliplatin-induced NF-kappaB activation, increases oxaliplatin cytotoxicity, and potentiates oxaliplatin-induced apoptosis in AIPC cells.
| M.Wt | 400.871 | |
| Formula | C15H14ClFN4O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wilson C, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):746-59.
2. Seaton A, et al. Carcinogenesis. 2008 Jun;29(6):1148-56.
3. Wilson C, et al. Mol Cancer Ther. 2008 Sep;7(9):2649-61.
4. Walters I, et la. Bioorg Med Chem Lett. 2008 Jan 15;18(2):798-803.
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