| Cat. No. |
Product Name |
Information |
| PC-61471 |
AZD8309
CXCR2 antagonist
|
AZD8309 is a potent and orally bioavailable CXCR2 antagonist that has been proposed to regulate the transmigration of neutrophils. |
| PC-61467 |
ST 016907
CCR4 antagonist
|
ST 016907 is a potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo. |
| PC-61466 |
AF-399 42016530
CCR4 antagonist
|
AF-399/42016530 is a potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo. |
| PC-61317 |
LY-2510924
CXCR4 inhibitor
|
LY-2510924 (LY2510924) is a potent and selective, cyclic peptide CXCR4 antagonist with IC50 of 0.079 nM, without apparent agonist activity. |
| PC-61294 |
KRH-3955
|
KRH-3955 is a potent, selective, orally bioavailable inhibitor of CXCR4 that efficiently inhibits SDF-1α binding to CXCR4 with IC50 of 0.61 nM. |
| PC-61293 |
Balixafortide
CXCR4 antagonist
|
Balixafortide (POL6326) is a potent, selective, peptidic CXCR4 antagonist that interferes with the tumor-protective microenvironment and sensitizes tumor cells to chemotherapy. |
| PC-61292 |
KRH-1636
CXCR4 inhibitor
|
KRH-1636 (KRH1636) is a potent, selective inhibitor of CXCR4 with IC50 of 13 nM, has no effect on CXCR1, CCR3, CCR4, or CCR5. |
| PC-61289 |
POL5551
CXCR4 inhibitor
|
POL5551 is a peptidic, potent and highly selective CXCR4 antagonist with IC50 of 1.7 nM. |
| PC-61173 |
NVP-BDZ 824
CXCR3 inhibitor
|
NVP-BDZ 824 is a potent, highly selective antagonist of chemokine receptor CXCR3 with binding IC50 of 146 nM, Ca2+-mobilization IC50 of 28 nM. |
| PC-61172 |
RAMX3
CXCR3 modulator
|
RAMX3 is a tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM. |
| PC-61171 |
FAUC 1104
CXCR3 agonist
|
FAUC 1104 is a potent, biased allosteric agonist of CXCR3 (pEC50=5.22) that activates solely G proteins, induces chemotaxis, but fails to induce receptor internalization or β-arrestin 2 recruitment. |
| PC-61170 |
FAUC 1036
CXCR3 agonist
|
FAUC 1036 is a potent, biased allosteric agonist of CXCR3 (pEC50=6.64), selectively induces chemotaxis and receptor internalization, and induces β-arrestin 2 recruitment without any stimulation of G proteins. |
