AZD8309 | CXCR2 antagonist | Probechem Biochemicals

Chemical Structure : AZD8309

AZD8309 (AZD-8309)

Catalog No.: PC-61471Not For Human Use, Lab Use Only.

AZD8309 is a potent and orally bioavailable CXCR2 antagonist that has been proposed to regulate the transmigration of neutrophils.

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Biological Activity

AZD8309 is a potent and orally bioavailable CXCR2 antagonist that has been proposed to regulate the transmigration of neutrophils.
AZD8309 significantly reduces MPO in the pancreas and lungs, and reduces intrapancreatic trypsin and elastase activity in caerulein-pancreatitis.
AZD8309 also reduces cathepsin B activity and MPO in taurocholate-pancreatitis; also antagonises the CCR2b receptor but it is 10-fold less potent than at CXCR2.

Physicochemical Properties

M.Wt	384.42
Formula	C15H14F2N4O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-((2,3-difluorobenzyl)thio)-7-((1-hydroxypropan-2-yl)amino)thiazolo[4,5-d]pyrimidin-2(3H)-one

References

1. Virtala R, et al. Clin Exp Allergy. 2012 Apr;42(4):590-6.

2. Leaker BR, et al. Respir Res. 2013 Dec 16;14:137.

3. Malla SR, et al. Pancreatology. 2016 Sep-Oct;16(5):761-9.

AZD8309 (AZD-8309)

Biological Activity

Physicochemical Properties

References

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