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PF-232798

Chemical Structure : PF-232798

CAS No.: 849753-15-7

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PF-232798 (PF232798;PF-00232798)

Catalog No.: PC-61582Not For Human Use, Lab Use Only.

PF-232798 (PF-00232798) is a potent CCR5 antagonist with IC50 of <0.1 nM in gp160 fusion assay, exhibits potent broad-spectrum anti-HIV-1 activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-232798 (PF-00232798) is a potent CCR5 antagonist with IC50 of <0.1 nM in gp160 fusion assay, exhibits potent broad-spectrum anti-HIV-1 activity.
    PF-232798 shows no significant affinity for hERG (binding IC50>12 uM); demonstrates antiviral activity against HIV BaL in PBMCs with IC50 of 2.0 nM.

    Physicochemical Properties

    M.Wt 509.67
    Formula C29H40FN5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide

    References

    1. Stupple PA, et al. J Med Chem. 2011 Jan 13;54(1):67-77.

    2. Abrol R, et al. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13040-5.

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