| Cat. No. |
Product Name |
Information |
| PC-20727 |
AZ12436092
CCR3 antagonist
|
AZ12436092 (AZ 12436092) is a potent, selective CCR3 antagonist with binding pKi value of 9.2. |
| PC-20726 |
YM-344031
CCR3 antagonist
|
YM-344031 is a potent, selective, brain-penetrable CCR3 antagonist with binding IC50 of 3.0 nM, inhibits ligand-induced Ca(2+) flux with IC50 of 5.4 nM. |
| PC-20725 |
YM-355179
CCR3 antagonist
|
YM-355179 is a potent selective, and orally available antagonist of CC chemokine receptor 3 (CCR3) with binding IC50 of 7.6 nM (CCL5). |
| PC-20724 |
SB-297006
CCR3 antagonist
|
SB-297006 is a potent, selective non-peptide CC chemokine receptor-3 (CCR3) antagonist, inhibits 125I-eotaxin binding to human eosinophils with IC50 of 60 nM. |
| PC-20723 |
SB-328437
CCR3 antagonist
|
SB-328437 is a potent, selective non-peptide CC chemokine receptor-3 (CCR3) antagonist, inhibits 125I-eotaxin binding to human eosinophils with IC50 of 4.5 nM. |
| PC-20542 |
J-113863
CCR1 inhibitor
|
J-113863 is a potent, selective, non-peptide antagonist of CCR1 with IC50 of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively. |
| PC-20541 |
UCB35625
CCR1 inhibitor
|
UCB35625 is a potent, selective inhibitor of CCR1 and CCR3, inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants with IC50 of 9.57 and 93.8 nM respectively. |
| PC-20531 |
INCB3284 bismesylate
CCR2 antagonist
|
INCB3284 bismesylate (INCB 3284, INCB003284) is a potent, selective and orally bioavailable hCCR2 antagonist with IC50 of 3.7 nM in antagonism of MCP-1 binding to hCCR2 and 4.7 nM in antagonism of chemotaxis activity. |
| PC-20530 |
INCB3284
CCR2 antagonist
|
INCB3284 (INCB 3284, INCB003284) is a potent, selective and orally bioavailable hCCR2 antagonist with IC50 of 3.7 nM in antagonism of MCP-1 binding to hCCR2 and 4.7 nM in antagonism of chemotaxis activity. |
| PC-20525 |
INCB9471
CCR5 antagonist
|
INCB9471 (INCB 9471) is a potent, selective, and orally bioavailable CCR5 antagonist with IC50 of 6.5 nM in MIP-1β assays, exhibits potent anti-HIV-1 activity against ADA and BaL strains with IC50 of 0.36 and 0.16 nM respectively. |
| PC-73171 |
USL311
CXCR4 inhibitor
|
USL311 is a potent, selective, orally bioavailable CXCR4 antagonist, with potential antineoplastic activity. |
| PC-61982 |
CCX-6239
|
CCX-6239 is a novel potent, orally available CCR4 inhibitor with potential utility in the treatment of allergic airways disease.. |
