Chemical Structure : YM-355179
CAS No.:
672957-37-8
YM-355179
(YM355179)
Catalog No.: PC-20725Not For Human Use, Lab Use Only.
YM-355179 is a potent selective, and orally available antagonist of CC chemokine receptor 3 (CCR3) with binding IC50 of 7.6 nM (CCL5).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
YM-355179 is a potent selective, and orally available antagonist of CC chemokine receptor 3 (CCR3) with binding IC50 of 7.6 nM (CCL5).
YM-355179 did not affect the binding of CCL5 to CCR1 or CCR5.
YM-355179 inhibited CCL11-induced, intracellular Ca(2+) influx, chemotaxis, and eosinophil degranulation with IC(50) values of 8.0, 24, and 29 nM, respectively.
YM-355179 did not affect any CC chemokine receptor (CCR1, CCR2, CCR4, or CCR5)-mediated Ca(2+) influx signals.
YM-355179 (1 mg/kg, oral) inhibited CCL11-induced shape change of whole blood eosinophils in cynomolgus monkeys.
YM-355179 (1 mg/kg, i.v.) also inhibited eosinophil infiltration into airways of cynomolgus monkeys after segmental bronchoprovocation with CCL11.
Physicochemical Properties
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M.Wt
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502.59
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Formula
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C29H31FN4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(N[C@H]1CN(CC2=CC=C3C=C(F)C=CC3=C2)CC1)/C=C4CCN(C(C5=NC=C(C)C=C5O)=O)CC\4
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References
1. Tatsuaki Morokata, et al. J Pharmacol Exp Ther. 2006 Apr;317(1):244-50.
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