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You are here:Home-Chemical Inhibitors & Agonists-GPCR-Chemokine Receptor (CCR and CXCR)-AZ12436092
AZ12436092

Chemical Structure : AZ12436092

CAS No.: 921204-43-5

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AZ12436092 (AZ 12436092)

Catalog No.: PC-20727Not For Human Use, Lab Use Only.

AZ12436092 (AZ 12436092) is a potent, selective CCR3 antagonist with binding pKi value of 9.2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AZ12436092 (AZ 12436092) is a potent, selective CCR3 antagonist with binding pKi value of 9.2.
AZ12436092 shows no additional activities against a panel of >100 GPCR receptors, and very weak activity at the hERG channel (pIC50=4.5) and H binding (pKi=6.8).
AZ12436092 inhibits CCL-24 (eotaxin-2) induced shape-change of eosinophils in human blood (pA2=7.9).
AZ12436092 displays excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species.

Physicochemical Properties

M.Wt 503.06
Formula C28H36ClFN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(O)[C@@](C)(N1CCC(CN2CCC(OC3=CC=C(Cl)C=C3C)CC2)CC1)CC4=CC=C(F)C=C4

References

1. Ash Bahl, et al. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6694-9.

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