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Chemical Structure : BMS-639623
Catalog No.: PC-20730Not For Human Use, Lab Use Only.
BMS-639623 is a potent, selective and orally bioavailable CCR3 antagonist with binding IC50 of 0.3 nM and chemotaxis IC50 of 0.04 nM.
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BMS-639623 is a potent, selective and orally bioavailable CCR3 antagonist with binding IC50 of 0.3 nM and chemotaxis IC50 of 0.04 nM.
BMS-639623 is selective against other 7TM receptors and ion channels.
BMS-639623 also shows activity in eotaxin-stimulated calcium flux in eosinophils with IC50 of 0.87 nM.
BMS-639623 shows poor binding and chemotaxis inhibition potency in the mouse (IC50=31, 870 nM, respectively).
BMS-639623 inhibits cyno eosinophil chemotaxis with IC50 of 0.15 nM.
BMS-639623 (5 mg/kg b.i.d.) reduces the allergen-dependent eosinophilia by 65%, 78%, and 82% in cyno study.
| M.Wt | 481.58 | |
| Formula | C25H32FN7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gardner DS, et al. Bioorg Med Chem Lett. 2008 Jan 15;18(2):586-95.
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