Chemical Structure : BMS-639623
CAS No.:
675122-44-8
BMS-639623
(BMS 639623)
Catalog No.: PC-20730Not For Human Use, Lab Use Only.
BMS-639623 is a potent, selective and orally bioavailable CCR3 antagonist with binding IC50 of 0.3 nM and chemotaxis IC50 of 0.04 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BMS-639623 is a potent, selective and orally bioavailable CCR3 antagonist with binding IC50 of 0.3 nM and chemotaxis IC50 of 0.04 nM.
BMS-639623 is selective against other 7TM receptors and ion channels.
BMS-639623 also shows activity in eotaxin-stimulated calcium flux in eosinophils with IC50 of 0.87 nM.
BMS-639623 shows poor binding and chemotaxis inhibition potency in the mouse (IC50=31, 870 nM, respectively).
BMS-639623 inhibits cyno eosinophil chemotaxis with IC50 of 0.15 nM.
BMS-639623 (5 mg/kg b.i.d.) reduces the allergen-dependent eosinophilia by 65%, 78%, and 82% in cyno study.
Physicochemical Properties
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M.Wt
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481.58
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Formula
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C25H32FN7O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(NC1=CC=CC(C2=NN=NN2C)=C1)N[C@@H]([C@@H](O)CN3C[C@H](CC4=CC=C(F)C=C4)CCC3)C
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References
1. Gardner DS, et al. Bioorg Med Chem Lett. 2008 Jan 15;18(2):586-95.
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