Chemical Structure : AZD3778
CAS No.:
485391-80-8
AZD3778
(AZD-3778, AZD 3778)
Catalog No.: PC-20729Not For Human Use, Lab Use Only.
AZD3778 (AZD-3778) is a dual CCR3 and H1-receptor antagonistwith Ki of 54 nM for guinea-pig H1-receptor, inhibits binding of CR3 radioligand 125I-eotaxin to human CCR3-receptor expressed on CHO-cells with IC50 of 8 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AZD3778 (AZD-3778) is a dual CCR3 and H1-receptor antagonistwith Ki of 54 nM for guinea-pig H1-receptor, inhibits binding of CR3 radioligand 125I-eotaxin to human CCR3-receptor expressed on CHO-cells with IC50 of 8 nM.
AZD3778 inhibits chemotaxis of eosinophils.
AZD3778 also inhibits the binding of a specific H1-radioligand, 3H-pyrilamin, to the human H1-receptor expressed on CHO-cells with an IC50 of 40 nM.
AZD3778 inhibits histamine-induced calcium flux with an IC50 of 63 nM in human HeLa-cells expressing the human H1-receptor.
AZD3778 affects allergic inflammation and symptoms in allergic rhinitis.
Physicochemical Properties
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M.Wt
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526.47
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Formula
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C24H29Cl2N3O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(N1CCC(N2CCC(OC3=CC=C(Cl)C(Cl)=C3)CC2)CC1)NS(=O)(C4=CC=C(C)C=C4)=O
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References
1. Lennart Greiff , et al. Respir Res. 2010 Feb 9;11(1):17.
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