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GW782415W

Chemical Structure : GW782415W

CAS No.: 408304-25-6

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GW782415W (GW782415)

Catalog No.: PC-20731Not For Human Use, Lab Use Only.

GW782415W (GW782415) is a potent, specific CCR3 antagonist, inhibits chemotaxis of human and murine eosinophils pKi of 8.08 and 7.85, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GW782415W (GW782415) is a potent, specific CCR3 antagonist, inhibits chemotaxis of human and murine eosinophils pKi of 8.08 and 7.85, respectively.
GW782415W ablates both the early and late phase reactions in a mouse model of allergic conjunctivitis.
Systemic administration of GW782415X reduced spontaneous CNV in JR5558 mice and laser-induced CNV in mouse and primate models in a dose-dependent fashion.

Physicochemical Properties

M.Wt 414.29
Formula C16H21Cl2N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(NCC1=NN(C)N=N1)NC[C@H]2CN(CC3=CC=C(Cl)C(Cl)=C3)CCO2

References

1. Takao Nakamura, et al. Immunol Res. 2005;33(3):213-21.

2. Nori Nagai, et al. Am J Pathol. 2015 Sep;185(9):2534-49.

3. Neda Farahi, et al. J Immunol. 2007 Jul 15;179(2):1264-73.

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