Chemical Structure : Ki19003
CAS No.:
444595-19-1
Ki19003
(Ki 19003)
Catalog No.: PC-20728Not For Human Use, Lab Use Only.
Ki19003 (Ki 19003) is a potent, specific CCR3 antagonist, inhibits the CCL11-induced migration of CCR3-expressing L1.2 cells with IC50 of 20 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Ki19003 (Ki 19003) is a potent, specific CCR3 antagonist, inhibits the CCL11-induced migration of CCR3-expressing L1.2 cells with IC50 of 20 nM.
Ki19003 does not inhibit CCL2- or CCL19-induced migration of CCR2- or CCR7-receptor-expressing cells even at 10 uM.
Ki19003 inhibits CCL11-induced migration of bone marrow–derived eosinophilic granulocytes in a concentration-dependent manner, shows no
cytotoxicity against the cells at 10 uM.
Ki19003 (3 or 10 mg/kg, oral) significantly inhibited the increase in the number of eosinophils in bronchoalveolar lavage fluid (BALF) of sensitized BALB/c mice.
Ki19003 also inhibited the increased production of transforming growth factor-beta1 in BALF and the amount of hydroxyproline in the lungs in a dose-dependent manner.
Ki19003 significantly attenuated allergen-induced subepithelial and peribronchial fibrosis.
Physicochemical Properties
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M.Wt
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528.90
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Formula
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C25H32Cl3N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(O)CCCN(C(C1=CC=C(Cl)C=C1)C)CCCCCNC(NCC2=CC=C(Cl)C=C2Cl)=O
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References
1. Masato Komai, et al. J Pharmacol Sci. 2010;112(2):203-13.
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